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Substance Name: Oxymetazoline hydrochloride [USAN:USP:JAN]
RN: 2315-02-8
UNII: K89MJ0S5VY
InChIKey: BEEDODBODQVSIM-UHFFFAOYSA-N

Note

  • A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)

Molecular Formula

  • C16-H24-N2-O.Cl-H

Molecular Weight

  • 296.8395
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-Agonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Nasal Decongestants
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Pharmaceutic Aid (Tablet and Capsule Diluent)
  • Reproductive Effect
  • Sympathomimetics
  • Vasoconstrictor Agents
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Names and Synonyms

Name of Substance

  • Oxymetazoline hydrochloride
  • Oxymetazoline hydrochloride [USAN:USP:JAN]

Synonyms

  • 2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline hydrochloride
  • 2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium chloride
  • 4-Way Nasal Spray
  • 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride
  • 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol monohydrochloride
  • Afrazine
  • Afrin
  • Afrin hydrochloride
  • Anefrin nasal
  • Dristan Long Lasting Nasal Mist
  • Duration 12 Hour Nasal Spray
  • Duration Nasal Spray
  • EINECS 219-015-0
  • H 990
  • LLiadin Mini Paediatric
  • Lliadine
  • Mucinex
  • Nafrine hydrochloride
  • Nasivin
  • Nasivine
  • Neo-Synephrine 12 Hour
  • Neo-Synephrine 12 Hour NTZ
  • Neonabel
  • Nezeril
  • Nostrilla
  • NSC 757254
  • Ocuclear
  • Operil
  • Oxymetazoline chloride
  • Oxymetazoline HCl
  • Oxymetazoline hydrochloride
  • Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride
  • Rhinolitan
  • Rhofade
  • Sch 9384
  • St. Joseph Nasal Spray for Children
  • Sudafed OM
  • UNII-K89MJ0S5VY
  • Vicks Sinex
  • Visine
  • Visine L.R.
  • Zicam

Systematic Names

  • Oxymetazoline hydrochloride
  • Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride
  • Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride

Mixture Names

  • Benzedrex Nasal Spray 12 Hour
  • Sinex VapoSpray Moisturizing 12-Hour Decongestant UltraFine Mist

Registry Numbers

CAS Registry Number

  • 2315-02-8

FDA UNII

  • K89MJ0S5VY

System Generated Number

  • 0002315028

Molecular Formulas

Molecular Formula

  • C16-H24-N2-O.Cl-H

Molecular Formula Fragments

  • C16-H24-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H

InChIKey

BEEDODBODQVSIM-UHFFFAOYSA-N

Smiles

Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 48mg/kg (48mg/kg)   Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966.
mouse LD50 oral 4700ug/kg (4.7mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
mouse LD50 subcutaneous 34mg/kg (34mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961.
rat LD50 intravenous 1070ug/kg (1.07mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961.
rat LD50 oral 680ug/kg (0.68mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1760, 1980.
rat LD50 subcutaneous 1630ug/kg (1.63mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961.