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Substance Name: Oxymetazoline hydrochloride [USAN:USP:JAN]
RN: 2315-02-8
UNII: K89MJ0S5VY
InChIKey: BEEDODBODQVSIM-UHFFFAOYSA-N
Note
- A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
Molecular Formula
- C16-H24-N2-O.Cl-H
Molecular Weight
- 296.8395
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-Agonists
- Autonomic Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Nasal Decongestants
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Pharmaceutic Aid (Tablet and Capsule Diluent)
- Reproductive Effect
- Sympathomimetics
- Vasoconstrictor Agents
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Names and Synonyms
Name of Substance
- Oxymetazoline hydrochloride
- Oxymetazoline hydrochloride [USAN:USP:JAN]
Synonyms
- 2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazoline hydrochloride
- 2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazolinium chloride
- 4-Way Nasal Spray
- 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride
- 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol monohydrochloride
- Afrazine
- Afrin
- Afrin hydrochloride
- Anefrin nasal
- Dristan Long Lasting Nasal Mist
- Duration 12 Hour Nasal Spray
- Duration Nasal Spray
- EINECS 219-015-0
- H 990
- LLiadin Mini Paediatric
- Lliadine
- Mucinex
- Nafrine hydrochloride
- Nasivin
- Nasivine
- Neo-Synephrine 12 Hour
- Neo-Synephrine 12 Hour NTZ
- Neonabel
- Nezeril
- Nostrilla
- NSC 757254
- Ocuclear
- Operil
- Oxymetazoline chloride
- Oxymetazoline HCl
- Oxymetazoline hydrochloride
- Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride
- Rhinolitan
- Rhofade
- Sch 9384
- St. Joseph Nasal Spray for Children
- Sudafed OM
- UNII-K89MJ0S5VY
- Vicks Sinex
- Visine
- Visine L.R.
- Zicam
Systematic Names
- Oxymetazoline hydrochloride
- Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-, monohydrochloride
- Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride
Mixture Names
- Benzedrex Nasal Spray 12 Hour
- Sinex VapoSpray Moisturizing 12-Hour Decongestant UltraFine Mist
Registry Numbers
CAS Registry Number
- 2315-02-8
FDA UNII
- K89MJ0S5VY
System Generated Number
- 0002315028
Molecular Formulas
Molecular Formula
- C16-H24-N2-O.Cl-H
Molecular Formula Fragments
- C16-H24-N2-O
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1HInChIKey
BEEDODBODQVSIM-UHFFFAOYSA-NSmiles
Cl.Cc1cc(c(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 48mg/kg (48mg/kg) | Farmaco, Edizione Pratica. Vol. 21, Pg. 204, 1966. | |
mouse | LD50 | oral | 4700ug/kg (4.7mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967. | |
mouse | LD50 | subcutaneous | 34mg/kg (34mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961. |
rat | LD50 | intravenous | 1070ug/kg (1.07mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961. |
rat | LD50 | oral | 680ug/kg (0.68mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1760, 1980. | |
rat | LD50 | subcutaneous | 1630ug/kg (1.63mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 1016, 1961. |