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Substance Name: Fosfomycin [USAN:INN:BAN]
RN: 23155-02-4
UNII: 2N81MY12TE
InChIKey: YMDXZJFXQJVXBF-HRFVKAFMSA-N

Note

  • An antibiotic produced by Streptomyces fradiae.

Molecular Formula

  • C3-H7-O4-P

Molecular Weight

  • 138.0583
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product

Names and Synonyms

Name of Substance

  • Fosfomycin
  • Fosfomycin [USAN:INN:BAN]

MeSH Heading

  • Fosfomycin

Synonyms

  • (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid
  • (2R-cis)-(3-Methyloxiranyl)phosphonic acid
  • 5-18-12-00526 (Beilstein Handbook Reference)
  • 883A
  • Antibiotic 833A
  • BRN 1680831
  • EINECS 245-463-1
  • Fosfocina
  • Fosfomicin
  • Fosfomicina
  • Fosfomicina [INN-Spanish]
  • Fosfomycin
  • Fosfomycine
  • Fosfomycine [INN-French]
  • Fosfomycinum
  • Fosfomycinum [INN-Latin]
  • Fosfonomycin
  • Infectophos
  • Levo-phosphonomycin
  • MK-955
  • Phosphomycin
  • Phosphonomycin
  • UNII-2N81MY12TE

Systematic Names

  • Fosfomycin
  • Phosphonic acid, (1,2-epoxypropyl)-, (1R,2S)-(-)-
  • Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-

Registry Numbers

CAS Registry Number

  • 23155-02-4

FDA UNII

  • 2N81MY12TE

System Generated Number

  • 0023155024

Structure Descriptors

InChI

1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3-/m0/s1

InChIKey

YMDXZJFXQJVXBF-HRFVKAFMSA-N

Smiles

C[C@@H]1O[C@H]1P(=O)(O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4gm/kg (4000mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 6, Pg. 426, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 94 deg C   EXP
log P (octanol-water) -1.230 (none)   EST
Atmospheric OH Rate Constant 1.03E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.