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Substance Name: Pipethanate ethobromide
RN: 23182-46-9
UNII: ZA38L5WD1K
InChIKey: VPUGSHLBERYQGC-UHFFFAOYSA-M

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C23-H30-N-O3.Br

Molecular Weight

  • 448.398
 
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Names and Synonyms

Name of Substance

  • Pipethanate ethobromide

Synonyms

  • 1-Ethyl-1-(2-hydroxyethyl)piperidinium bromide benzilate
  • 2-(1-Piperidino)-ethyl benzilate ethylbromide
  • 2-(1-Piperidino)ethyl benzilate ethobromide
  • Panpurol
  • PB-106
  • Pipethanate ethylbromide
  • UNII-ZA38L5WD1K

Systematic Name

  • Piperidinium, 1-ethyl-1-(2-hydroxyethyl)-, bromide, benzilate (ester)

Registry Numbers

CAS Registry Number

  • 23182-46-9

FDA UNII

  • ZA38L5WD1K

System Generated Number

  • 0023182469

Molecular Formulas

Molecular Formula

  • C23-H30-N-O3.Br

Molecular Formula Fragments

  • Br
  • C23-H30-N-O3
  • COMPONENT

Structure Descriptors

InChI

1S/C23H30NO3.BrH/c1-2-24(16-10-5-11-17-24)18-19-27-22(25)23(26,20-12-6-3-7-13-20)21-14-8-4-9-15-21;/h3-4,6-9,12-15,26H,2,5,10-11,16-19H2,1H3;1H/q+1;/p-1

InChIKey

VPUGSHLBERYQGC-UHFFFAOYSA-M

Smiles

[N+]1(CCCCC1)(CCOC(=O)C(c1ccccc1)(c1ccccc1)O)CC.[BrH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 73mg/kg (73mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
mouse LD50 intravenous 18mg/kg (18mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
mouse LD50 oral 1001mg/kg (1001mg/kg)   "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1972Vol. -, Pg. 96, 1972.
mouse LD50 subcutaneous 288mg/kg (288mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rabbit LD50 intramuscular 382mg/kg (382mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rabbit LD50 intravenous 32mg/kg (32mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rat LD50 intramuscular 1570mg/kg (1570mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rat LD50 intraperitoneal 121mg/kg (121mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rat LD50 intravenous 21mg/kg (21mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rat LD50 oral 4600mg/kg (4600mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rat LD50 subcutaneous 1350mg/kg (1350mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.