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Substance Name: SK&F 24260
RN: 23191-75-5
InChIKey: ACZJZGLXRPZSLI-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H22-F3-N-O4

Molecular Weight

  • 397.3908
 
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Names and Synonyms

Name of Substance

  • SK&F 24260

Synonyms

  • 2,6-Dimethyl-3,5-dicarbomethoxy-4-(o-trifluoromethylphenyl)-1,4-dihydropyridine
  • 2,6-Dimethyl-3,5-dicarbomethoxy-4-(o-trifluoromethylphenyl)-1,4-dihydropyridine [French]
  • 4-(2-Trifluoromethylphenyl)-3,5-dicarbethoxy-2,6-dimethyl-1,4-dihydropyridine
  • 5-22-04-00275 (Beilstein Handbook Reference)
  • BRN 0500244
  • Ftorin
  • Ftorin (pharmaceutical)
  • SKF 24260

Systematic Names

  • 1,4-Dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylic acid diethyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-, diethyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(alpha,alpha,alpha-trifluoro-o-tolyl)-, diethyl ester

Registry Numbers

CAS Registry Number

  • 23191-75-5

System Generated Number

  • 0023191755

Structure Descriptors

InChI

1S/C20H22F3NO4/c1-5-27-18(25)15-11(3)24-12(4)16(19(26)28-6-2)17(15)13-9-7-8-10-14(13)20(21,22)23/h7-10,17,24H,5-6H2,1-4H3

InChIKey

ACZJZGLXRPZSLI-UHFFFAOYSA-N

Smiles

CCOC(=O)C1=C(C)NC(=C(C1c2ccccc2C(F)(F)F)C(=O)OCC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 700ug/kg (0.7mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Medicinal Chemistry. Vol. 17, Pg. 956, 1974.
mouse LD50 intraperitoneal 38mg/kg (38mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Pharmaceutical Chemistry Journal Vol. 16, Pg. 817, 1982.
mouse LD50 oral 1480mg/kg (1480mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Journal of Medicinal Chemistry. Vol. 17, Pg. 956, 1974.
rat LD50 oral 1225mg/kg (1225mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Medicinal Chemistry. Vol. 17, Pg. 956, 1974.
rat LDLo intravenous 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Medicinal Chemistry. Vol. 17, Pg. 956, 1974.