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Substance Name: Fluorescein [USP:BAN:JAN]
RN: 2321-07-5
UNII: TPY09G7XIR
InChIKey: GNBHRKFJIUUOQI-UHFFFAOYSA-N
Note
- A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
Molecular Formula
- C20-H12-O5
Molecular Weight
- 332.3098
- All
- Classifications
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- Names & Synonyms
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- Structure Descriptors
- Toxicity
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Classification Codes
- Coloring Agents
- Contrast Media
- Diagnostic Aid (Corneal Trauma Indicator)
- Diagnostic Uses of Chemicals
- Fluorescent Dyes
- Indicators and Reagents
- Luminescent Agents
- Mutation Data
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Names and Synonyms
Name of Substance
- 3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one
- CI 45350:1
- D & C Yellow no. 7
- Fluorescein
- Fluorescein [USP:BAN:JAN]
- Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-
MeSH Heading
- Fluorescein
Synonyms
- 11712 Yellow
- 3',6'-Dihydroxyfluoran
- 3',6'-Dihydroxyspiro(isobenzofuran-1(3H),9'(9H)-xanthen)-3-one
- 3,6-Dihydroxyspiro(xanthene-9,3'-phthalide)
- 3,6-Fluorandiol
- 3H-Xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-
- 5-19-06-00456 (Beilstein Handbook Reference)
- 9-(o-Carboxyphenyl)-6-hydroxy-3-isoxanthenone
- 9-(o-Carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
- Benzoic acid, 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
- Benzoic acid, o-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
- BRN 0094324
- C.I. 45350:1
- C.I. Solvent Yellow 94
- CCRIS 7076
- CI 45350:1
- D and C Yellow No. 7
- D+C Yellow No. 7
- EC 219-031-8
- EINECS 219-031-8
- Fluoran, 3',6'-dihydroxy-
- Fluorescein
- Fluorescein acid
- Fluorescein Red
- Fluoresceine
- Fluorescite
- Hidacid fluorescein
- HSDB 2128
- Japan Yellow 201
- Japan Yellow No. 201
- NSC 667256
- Resorcinolphthalein
- Soap Yellow F
- Solvent Yellow 94
- Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one,3'6'-dihydroxy-
- UNII-TPY09G7XIR
- Yellow fluorescein
- Zlut kysela 73
- Zlut kysela 73 [Czech]
Systematic Names
- 2-(6-Hydroxy-3-oxo-(3H)-xanthen-9-yl)benzoic acid
- D&C Yellow No. 7
- Fluorescein
- Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-
Superlist Name
- Fluorescein
Registry Numbers
CAS Registry Number
- 2321-07-5
FDA UNII
- TPY09G7XIR
Other Registry Numbers
- 126605-73-0
- 213880-86-5
- 518-46-7
- 770677-61-7
Related Registry Numbers
- 518-47-8 (di-hydrochloride salt)
- 6417-85-2 (di-potassium salt)
System Generated Number
- 0002321075
Structure Descriptors
InChI
InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22HInChIKey
GNBHRKFJIUUOQI-UHFFFAOYSA-NSmiles
Oc1ccc2c(Oc3cc(O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | unreported | 400mg/kg (400mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
man | TDLo | intravenous | 7143nL/kg (7143mL/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: NAUSEA OR VOMITING | American Journal of Ophthalmology. Vol. 126, Pg. 837, 1998. |
mouse | LD50 | intravenous | 300mg/kg (300mg/kg) | United States Patent Document. Vol. #4775625, | |
mouse | LDLo | unreported | 600mg/kg (600mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
rabbit | LDLo | intravenous | 300mg/kg (300mg/kg) | International Journal of Leprosy and Other Mycobacterial Diseases. Vol. 2, Pg. 257, 1934. | |
rat | LDLo | intraperitoneal | 600mg/kg (600mg/kg) | International Journal of Leprosy and Other Mycobacterial Diseases. Vol. 2, Pg. 257, 1934. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 315 dec | deg C | EXP | |
log P (octanol-water) | 3.350 | (none) | EST | |
Atmospheric OH Rate Constant | 2.00E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.