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Substance Name: Brotianide [INN:BAN]
RN: 23233-88-7
UNII: 30OGU6XH7S
InChIKey: NRFGEDASJHBPPN-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H10-Br2-Cl-N-O2-S

Molecular Weight

  • 463.576
 
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Names and Synonyms

Name of Substance

  • Brotianide
  • Brotianide [INN:BAN]

Synonyms

  • 2-Brom-6-(4-bromphenylthiocarbamoyl)-4-chlorphenylacetat
  • 3,4'-Dibromo-5-chlorothiosalicylanilide acetate (ester)
  • BAY 4059 Va
  • BAY-VA 4059
  • Benzenecarbothioamide, 2-(acetyloxy)-3-bromo-N-(4-bromophenyl)-5-chloro-
  • Benzoic acid, 2-bromo-6-(N-(p-bromophenyl)thiocarbamoyl)-4-chloro-
  • BRN 2819612
  • Brotianida
  • Brotianida [INN-Spanish]
  • Brotianide
  • Brotianidum
  • Brotianidum [INN-Latin]
  • Dirian
  • EINECS 245-505-9
  • FB a 4059
  • FBA 4059
  • UNII-30OGU6XH7S

Systematic Names

  • 2-Acetoxy-3-bromo-5-chloro-N-(4'-bromophenylthio)benzamide
  • 3,4'-Dibromo-5-chlorothiosalicylanilide acetate (ester)
  • Brotianide
  • Salicylanilide, 3,4'-dibromo-5-chlorothio-, acetate (ester)

Registry Numbers

CAS Registry Number

  • 23233-88-7

FDA UNII

  • 30OGU6XH7S

System Generated Number

  • 0023233887

Structure Descriptors

InChI

1S/C15H10Br2ClNO2S/c1-8(20)21-14-12(6-10(18)7-13(14)17)15(22)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,22)

InChIKey

NRFGEDASJHBPPN-UHFFFAOYSA-N

Smiles

c1(C(Nc2ccc(cc2)Br)=S)c(c(Br)cc(c1)Cl)OC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Annales Pharmaceutiques Francaises. Vol. 33, Pg. 273, 1975.
domestic animals - goat/sheep LD50 oral 40mg/kg (40mg/kg)   Fortschritte der Arzneimittelforschung. Progress in Drug Research. Vol. 17, Pg. 108, 1973.
mouse LD50 oral 184mg/kg (184mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Annales Pharmaceutiques Francaises. Vol. 33, Pg. 273, 1975.
rabbit LD50 oral 50mg/kg (50mg/kg)   Annales Pharmaceutiques Francaises. Vol. 33, Pg. 273, 1975.
rat LD50 oral 3gm/kg (3000mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Annales Pharmaceutiques Francaises. Vol. 33, Pg. 273, 1975.
rat LD50 skin > 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE Annales Pharmaceutiques Francaises. Vol. 33, Pg. 273, 1975.