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Substance Name: Ritodrine hydrochloride [USAN:USP:JAN]
RN: 23239-51-2
UNII: ESJ56Q60GC
InChIKey: IDLSITKDRVDKRV-JSUROZADSA-N

Note

  • Adrenergic beta-agonist used to control premature labor.

Molecular Formula

  • C17-H21-N-O3.Cl-H

Molecular Weight

  • 323.8178
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Relaxant (Smooth Muscle)
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ritodrine hydrochloride
  • Ritodrine hydrochloride [USAN:USP:JAN]

Synonyms

  • Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-, hydrochloride, (R*,S*)-
  • EINECS 245-514-8
  • erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl alcohol hydrochloride
  • NSC 291565
  • Pre-Par
  • Ritodrine HCl
  • Ritodrine hydrochloride
  • Ritodrine hydrochloride in dextrose 5% in plastic container
  • UNII-ESJ56Q60GC
  • Utopar
  • Yutopar

Systematic Names

  • (R*,S*)-4-Hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)benzyl alcohol hydrochloride
  • Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-, hydrochloride, (R*,S*)-
  • Benzyl alcohol, p-hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)-, hydrochloride, erythro-

Registry Numbers

CAS Registry Number

  • 23239-51-2

FDA UNII

  • ESJ56Q60GC

System Generated Number

  • 0023239512

Molecular Formulas

Molecular Formula

  • C17-H21-N-O3.Cl-H

Molecular Formula Fragments

  • C17-H21-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m1./s1

InChIKey

IDLSITKDRVDKRV-JSUROZADSA-N

Smiles

Cl.C[C@@H](NCCc1ccc(O)cc1)[C@@H](O)c2ccc(O)cc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 128mg/kg (128mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
dog LD50 oral 2458mg/kg (2458mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

CARDIAC: CHANGE IN RATE
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
mouse LD50 intramuscular 433mg/kg (433mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
mouse LD50 intraperitoneal 265mg/kg (265mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 intravenous 69mg/kg (69mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 oral 687mg/kg (687mg/kg)   Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985.
mouse LD50 subcutaneous 815mg/kg (815mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intramuscular 910mg/kg (910mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intraperitoneal 330mg/kg (330mg/kg) LIVER: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 intravenous 83mg/kg (83mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BLOOD: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 oral 1840mg/kg (1840mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
rat LD50 subcutaneous 980mg/kg (980mg/kg) BLOOD: CHANGES IN SPLEEN

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984.
women TDLo intravenous 14508ug/kg/15 (14.508mg/kg)   British Medical Journal. Vol. 2, Pg. 1194, 1978.