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Substance Name: Guanabenz acetate [USAN:USP:JAN]
RN: 23256-50-0
UNII: 443O19GK1A
InChIKey: MCSPBPXATWBACD-GAYQJXMFSA-N

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C8-H8-Cl2-N4.C2-H4-O2

Molecular Weight

  • 291.1368
 
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Names and Synonyms

Name of Substance

  • Guanabenz acetate
  • Guanabenz acetate [USAN:USP:JAN]

Synonyms

  • ((2,6-Dichlorobenzylidene)amino)guanidine acetate
  • ((2,6-Dichlorobenzylidene)amino)guanidine monoacetate
  • BR 750
  • EINECS 245-534-7
  • Guanabenz acetate
  • HSDB 6535
  • Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, monoacetate
  • UNII-443O19GK1A
  • WY 8678 acetate
  • WY-8678 acetate
  • Wytensin

Systematic Names

  • 3-((2,6-Dichlorophenyl)methylene)carbazamidine monoacetate
  • Guanidine, ((2,6-dichlorobenzylidene)amino)-, monoacetate
  • Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, monoacetate

Registry Numbers

CAS Registry Number

  • 23256-50-0

FDA UNII

  • 443O19GK1A

Related Registry Number

  • 5051-62-7 (Parent)

System Generated Number

  • 0023256500

Molecular Formulas

Molecular Formula

  • C8-H8-Cl2-N4.C2-H4-O2

Molecular Formula Fragments

  • C2-H4-O2
  • C8-H8-Cl2-N4
  • COMPONENT

Structure Descriptors

InChI

1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;

InChIKey

MCSPBPXATWBACD-GAYQJXMFSA-N

Smiles

CC(=O)O.NC(=N)N\N=C\c1c(Cl)cccc1Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 1mg/kg (1mg/kg) BEHAVIORAL: SLEEP

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
Annals of Internal Medicine. Vol. 102, Pg. 787, 1985.
mouse LD50 intraperitoneal 75mg/kg (75mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: GENERAL ANESTHETIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
mouse LD50 oral 260mg/kg (260mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: GENERAL ANESTHETIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
mouse LD50 subcutaneous 89mg/kg (89mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
rat LD50 intraperitoneal 62mg/kg (62mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
rat LD50 oral 238mg/kg (238mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
rat LD50 subcutaneous 84mg/kg (84mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 4571, 1982.
women TDLo oral 1mg/kg (1mg/kg) CARDIAC: PULSE RATE

BEHAVIORAL: SLEEP
Annals of Internal Medicine. Vol. 102, Pg. 787, 1985.