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Substance Name: Levoxadrol hydrochloride [USAN]
RN: 23257-58-1
UNII: 3ARD9VMM81
InChIKey: GYPWNVSWCIMIHQ-VOMIJIAVSA-N

Classification Codes

  • Analgesics
  • Anesthetic (Local)
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Relaxant (Smooth Muscle)
  • Sensory System Agents

Molecular Formula

  • C20-H23-N-O2.Cl-H

Molecular Weight

  • 345.8676
 
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Names and Synonyms

Name of Substance

  • Levoxadrol hydrochloride [USAN]

Synonyms

  • (-)-2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine hydrochloride
  • CL 912C
  • CL-912C
  • l-2,2-Diphenyl-4-(2-piperidyl)-1,3-dioxolane hydrochloride
  • l-2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine hydrochloride
  • l-Dioxadrol hydrochloride
  • Levoxadrol HCl
  • Levoxadrol hydrochloride
  • Levoxan
  • NIH 10374
  • NSC 526063
  • Relane
  • U 22559A
  • U-22,304A
  • UNII-3ARD9VMM81

Systematic Names

  • Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-, hydrochloride
  • Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-, hydrochloride, l-

Registry Numbers

CAS Registry Number

  • 23257-58-1

FDA UNII

  • 3ARD9VMM81

Related Registry Number

  • 4741-41-7 (Parent)

System Generated Number

  • 0023257581

Molecular Formulas

Molecular Formula

  • C20-H23-N-O2.Cl-H

Molecular Formula Fragments

  • C20-H23-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H23NO2.ClH/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18;/h1-6,9-12,18-19,21H,7-8,13-15H2;1H/t18-,19+;/m1./s1

InChIKey

GYPWNVSWCIMIHQ-VOMIJIAVSA-N

Smiles

c1ccc(cc1)C2(OC[C@H](O2)[C@H]3CCCCN3)c4ccccc4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 230mg/kg (230mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 105, 1965.
rabbit LD50 intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ANTICONVULSANT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 105, 1965.
rat LD50 oral 310mg/kg (310mg/kg) BEHAVIORAL: ATAXIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 153, Pg. 105, 1965.