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Substance Name: Nefopam hydrochloride [USAN]
RN: 23327-57-3
UNII: 685J48E13W
InChIKey: CNNVSINJDJNHQK-UHFFFAOYSA-N

Note

  • Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Molecular Formula

  • C17-H19-N-O.Cl-H

Molecular Weight

  • 289.804
 

Classification Codes

  • Analgesic
  • Analgesics
  • Analgesics, Non-Narcotic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Nefopam hydrochloride
  • Nefopam hydrochloride [USAN]

Synonyms

  • 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride
  • 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride
  • Acupan
  • Ajan
  • EINECS 245-585-5
  • Fenazoxine hydrochloride
  • Lenipan
  • Leoplexamin
  • Nefopam HCl
  • Nefopam hydrochloride
  • Oxadol
  • Pallopikeron
  • R 738
  • Sinalgico
  • UNII-685J48E13W

Systematic Names

  • 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-, hydrochloride
  • 1H-2,5-Benzoxazocine, 5-methyl-1-phenyl-3,4,5,6-tetrahydro-, hydrochloride
  • 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride

Registry Numbers

CAS Registry Number

  • 23327-57-3

FDA UNII

  • 685J48E13W

Related Registry Number

  • 13669-70-0 (Parent)

System Generated Number

  • 0023327573

Molecular Formulas

Molecular Formula

  • C17-H19-N-O.Cl-H

Molecular Formula Fragments

  • C17-H19-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChIKey

CNNVSINJDJNHQK-UHFFFAOYSA-N

Smiles

CN1CCOC(c2ccccc2C1)c3ccccc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 30mg/kg (30mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
dog LD50 intravenous 20mg/kg (20mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
dog LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
mouse LD50 intramuscular 53mg/kg (53mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
mouse LD50 intraperitoneal 70mg/kg (70mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
mouse LD50 intravenous 45mg/kg (45mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
mouse LD50 oral 119mg/kg (119mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
rat LD50 intramuscular 57mg/kg (57mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.
rat LD50 intravenous 28mg/kg (28mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 269, 1972.
rat LD50 oral 80mg/kg (80mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 33, Pg. 46, 1975.