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Substance Name: Vinleurosine [INN]
RN: 23360-92-1
UNII: 803MS59U85
InChIKey: LPGWZGMPDKDHEP-NVDFJPPOSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C46-H56-N4-O9

Molecular Weight

  • 808.9674
 
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Names and Synonyms

Name of Substance

  • Leurosine
  • Vinleurosine [INN]

Synonyms

  • 4-27-00-09622 (Beilstein Handbook Reference)
  • Amotin
  • Amotin [Russian]
  • BRN 0079636
  • HSDB 3506
  • NSC 528004
  • UNII-803MS59U85
  • Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'alpha,4'alpha)-
  • Vinleurosina
  • Vinleurosina [INN-Spanish]
  • Vinleurosine
  • Vinleurosinum
  • Vinleurosinum [INN-Latin]

Systematic Names

  • Leurosine
  • Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'-alpha,4'-alpha)- (9CI)

Registry Numbers

CAS Registry Number

  • 23360-92-1

FDA UNII

  • 803MS59U85

Other Registry Numbers

  • 11032-39-6
  • 1358-98-1
  • 1362-18-1
  • 27776-07-4
  • 53716-28-2

System Generated Number

  • 0023360921

Structure Descriptors

InChI

1S/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,15,17-20,23-25H2,1-7H3/t27-,36+,37-,38+,39+,42+,43-,44+,45-,46-/m0/s1

InChIKey

LPGWZGMPDKDHEP-NVDFJPPOSA-N

Smiles

CC[C@]12C[N@@]3CCc4c5ccccc5[nH]c4[C@](C[C@@H](C3)[C@H]1O2)(c6cc7c(cc6OC)N([C@@H]8[C@]79CCN1[C@H]9[C@@](C=CC1)([C@H]([C@@]8(C(=O)OC)O)OC(=O)C)CC)C)C(=O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intraperitoneal 12mg/kg (12mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.
mouse LD50 intravenous 105mg/kg (105mg/kg)   Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984.
rat LD50 intraperitoneal 15200ug/kg (15.2mg/kg)   Pharmaceutical Chemistry Journal Vol. 18, Pg. 667, 1984.