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Substance Name: Bisbenzimidazole trihydrochloride
RN: 23491-45-4
UNII: MHT095273M
InChIKey: SMNPLAKEGAEPJD-UHFFFAOYSA-N

Note

  • A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.

Molecular Formula

  • C25-H24-N6-O.3Cl-H

Molecular Weight

  • 533.8883
 

Classification Code

  • Mutation Data
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Names and Synonyms

Results Name

  • Bisbenzimidazole trihydrochloride

Name of Substance

  • Bisbenzimidazole

MeSH Heading

  • Bisbenzimidazole

Synonyms

  • 33258 Hoechst
  • 4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride
  • Bisbenzimidazole trihydrochloride
  • Bisbenzimide
  • EINECS 245-690-6
  • H 33258
  • HOE 33258
  • Hoechst 33258
  • Hoechst Dye 33258
  • NSC-322921
  • Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride
  • Pibenzimol HCl
  • UNII-MHT095273M

Systematic Names

  • p-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol trihydrochloride
  • Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3)
  • Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, trihydrochloride
  • Phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1H-benzimidazol)-2'-yl)-, hydrochloride (1:3)
  • Phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride

Registry Numbers

CAS Registry Number

  • 23491-45-4

FDA UNII

  • MHT095273M

Other Registry Numbers

  • 53025-60-8
  • 863126-37-8
  • 91932-18-2
  • 93038-90-5

System Generated Number

  • 0023491454

Molecular Formulas

Molecular Formula

  • C25-H24-N6-O.3Cl-H

Molecular Formula Fragments

  • C25-H24-N6-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H24N6O.3ClH/c1-30-10-12-31(13-11-30)18-5-9-21-23(15-18)29-25(27-21)17-4-8-20-22(14-17)28-24(26-20)16-2-6-19(32)7-3-16;;;/h2-9,14-15,32H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H

InChIKey

SMNPLAKEGAEPJD-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)c2ccc3c(c2)[nH]c(n3)c4ccc5c(c4)[nH]c(n5)c6ccc(cc6)O.Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 22400ug/kg (22.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. PB84-171206,
mouse LD50 intravenous 36900ug/kg (36.9mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. PB84-171206,
rat LD50 intravenous 32200ug/kg (32.2mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. PB84-171206,