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Substance Name: Butropipazone
RN: 2354-61-2
InChIKey: QPHRVUMZLUQZGU-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H23-F-N2-O

Molecular Weight

  • 326.413
 
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Names and Synonyms

Results Name

  • Butropipazone

Synonyms

  • 4'-Fluoro-4-(1-(4-phenyl)piperazino)butyrophenone
  • 5-23-02-00209 (Beilstein Handbook Reference)
  • BPZ
  • BRN 0895232
  • Butropipazon
  • Butropipazone
  • Butyropipazone
  • Galvanisone
  • gamma-(4-Phenylpiperazino)-4-fluorobutyrophenone
  • NSC 170975
  • R 1892

Systematic Names

  • 1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)- (9CI)
  • Butyrophenone, 4'-fluoro-4-(4-phenyl-1-piperazinyl)-

Registry Numbers

CAS Registry Number

  • 2354-61-2

System Generated Number

  • 0002354612

Structure Descriptors

InChI

1S/C20H23FN2O/c21-18-10-8-17(9-11-18)20(24)7-4-12-22-13-15-23(16-14-22)19-5-2-1-3-6-19/h1-3,5-6,8-11H,4,7,12-16H2

InChIKey

QPHRVUMZLUQZGU-UHFFFAOYSA-N

Smiles

N1(c2ccccc2)CCN(CCCC(c2ccc(F)cc2)=O)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 76mg/kg (76mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 186, 1972.
mouse LD50 intravenous 24mg/kg (24mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 186, 1972.
mouse LD50 oral 650mg/kg (650mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
mouse LD50 subcutaneous > 160mg/kg (160mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.
mouse LD50 unreported 450mg/kg (450mg/kg)   Clinical Pharmacology and Therapeutics Vol. 3, Pg. 432, 1962.
rat LD50 intravenous 32mg/kg (32mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 186, 1972.
rat LD50 oral 550mg/kg (550mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 15, Pg. 485, 1977.
rat LD50 subcutaneous 550mg/kg (550mg/kg) AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING
Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967.