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Substance Name: Droxidopa [USAN:INN:JAN]
RN: 23651-95-8
UNII: J7A92W69L7
InChIKey: QXWYKJLNLSIPIN-JGVFFNPUSA-N

Note

  • A synthetic precursor of norepinephrine that is used in the treatment of PARKINSONIAN DISORDERS and ORTHOSTATIC HYPOTENSION.

Molecular Formula

  • C9-H11-N-O5

Molecular Weight

  • 213.1879
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Neurogenic Hypotension
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Droxidopa
  • Droxidopa [USAN:INN:JAN]

MeSH Heading

  • Droxidopa

Synonyms

  • (-)-(2S,3R)-2-Amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid
  • DOPS
  • Droxidopa
  • Droxidopa [Latin]
  • L-DOPS
  • L-threo-3-(3,4-Dihydroxyphenyl)serine
  • L-Threodops
  • L-Tyrosine, beta,3-dihydroxy-, threo-
  • Norethra
  • Northera
  • SM 5688
  • threo-Dopaserine
  • UNII-J7A92W69L7

Systematic Names

  • (-)-threo-3-(3,4-Dihydroxyphenyl)-L-serine
  • L-Tyrosine, beta,3-dihydroxy-, (beta-R)-
  • L-Tyrosine, beta,3-dihydroxy-, threo-
  • Serine, 3-(3,4-dihydroxyphenyl)-, L-threo-

Registry Numbers

CAS Registry Number

  • 23651-95-8

FDA UNII

  • J7A92W69L7

System Generated Number

  • 0023651958

Structure Descriptors

InChI

InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

InChIKey

QXWYKJLNLSIPIN-JGVFFNPUSA-N

Smiles

N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 5gm/kg (5000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 40, Pg. 1935, 1989.
monkey LD50 oral > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Yakkyoku. Pharmacy. Vol. 40, Pg. 1935, 1989.
mouse LD50 intravenous > 100mg/kg (100mg/kg)   Drugs in Japan Vol. -, Pg. 758, 1990.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 758, 1990.
mouse LD50 subcutaneous > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 758, 1990.
rat LD50 intravenous 16mg/kg (16mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15(Suppl,
rat LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. -, Pg. 758, 1990.
rat LD50 subcutaneous 84mg/kg (84mg/kg)   Drugs in Japan Vol. -, Pg. 758, 1990.