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Substance Name: Methylprednisolone sodium succinate [USP:JAN]
RN: 2375-03-3
UNII: LEC9GKY20K
InChIKey: FQISKWAFAHGMGT-SGJOWKDISA-M

Notes

  • A PREDNISOLONE derivative with similar anti-inflammatory action.
  • A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.

Molecular Formulas

  • C26-H33-Na-O8
  • C26-H33-O8.Na
  • C26-H34-O8.Na

Molecular Weight

  • 496.529
 

Classification Codes

  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Methylprednisolone sodium succinate
  • Methylprednisolone sodium succinate [USP:JAN]

Synonyms

  • 11-beta,17,21-Trihydroxy-6-alpha-methyl-1,4-pregnadiene-3,20-dione 21-(sodium succinate)
  • 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-(sodium succinate)
  • 6-alpha-Methylprednisolone sodium succinate
  • 6alpha-Methylprednisolone 21-hemisuccinate sodium salt
  • 6alpha-Methylprednisolone 21-sodium hemisuccinate
  • 6alpha-Methylprednisolone 21-sodium succinate
  • 6alpha-Methylprednisolone sodium hemisuccinate
  • 6alpha-Methylprednisolone sodium succinate
  • 6alpha-Methylpregnisolone 21-sodium succinate
  • A-Methapred
  • Asmacortone
  • Corticel
  • Cryosolona
  • Cryosolona [inj.]
  • EINECS 219-156-8
  • Emmetipi
  • Firmacort Fiale
  • Lemod Solu
  • M-6-P
  • Medrate
  • Medrate [inj.]
  • Methylprednisolone sodium hemisuccinate
  • Methylprednisolone sodium succinate
  • Methylprednisolone succinate sodium salt
  • Metypred
  • Metypred [inj.]
  • Metypresol
  • Nirypan solubile
  • NSC 48989
  • Omnacortil
  • Prednilem
  • Prednisolone, 6alpha-methyl-, succinate, sodium salt
  • Prednol
  • Prednol [inj.]
  • Sodium methylprednisolone succinate
  • Sol Melcort
  • Solu Medrol
  • Solu-Medrol
  • Solu-Medrone
  • Solumedrol
  • Succinic acid, 21-monoester with 11beta,17,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione, monosodium salt
  • U 9088
  • Ubrason solubile
  • Ubrason solubile [inj.]
  • UNII-LEC9GKY20K
  • Urbason solubile

Systematic Names

  • Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt
  • Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(hydrogen succinate), monosodium salt (8CI)
  • Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, monosodium salt, (6alpha,11beta)-

Registry Numbers

CAS Registry Number

  • 2375-03-3

FDA UNII

  • LEC9GKY20K

Related Registry Number

  • 2921-57-5 (Parent)

System Generated Number

  • 0002375033

Molecular Formulas

Molecular Formulas

  • C26-H33-Na-O8
  • C26-H33-O8.Na
  • C26-H34-O8.Na

Molecular Formula Fragments

  • C26-H33-O8
  • C26-H34-O8
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChIKey

FQISKWAFAHGMGT-SGJOWKDISA-M

Smiles

C1[C@H]2[C@H]3[C@@]([C@](C(COC(CCC(=O)[O-])=O)=O)(O)CC3)(C[C@@H]([C@@H]2[C@@]2(C(=CC(=O)C=C2)[C@H]1C)C)O)C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 571ug/kg/1M-C (0.571mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Journal of Emergency Medicine. Vol. 5, Pg. 42, 1987.
man TDLo intravenous 43mg/kg/3D-I (43mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Annals of Internal Medicine. Vol. 104, Pg. 58, 1986.
mouse LD50 intraperitoneal 880mg/kg (880mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
mouse LD50 intravenous 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
mouse LD50 oral > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
mouse LD50 subcutaneous 860mg/kg (860mg/kg) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
rat LD50 intraperitoneal 640mg/kg (640mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
rat LD50 intravenous 640mg/kg (640mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
rat LD50 oral > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
rat LD50 subcutaneous 750mg/kg (750mg/kg) BEHAVIORAL: STIFFNESS

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 633, 1974.
women TDLo intravenous 60ug/kg/3D-I (0.06mg/kg) CARDIAC: PULSE RATE Scandinavian Journal of Rheumatology. Vol. 15, Pg. 302, 1986.