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Substance Name: Probenecid sodium
RN: 23795-03-1
UNII: FXB45Q4ZVK
InChIKey: QCCCFHDTBTUDEA-UHFFFAOYSA-M

Note

  • The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

Molecular Formula

  • C13-H18-N-O4-S.Na

Molecular Weight

  • 307.344
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Results Name

  • Probenecid sodium

Name of Substance

  • Probenecid sodium

Synonyms

  • Benemid, sodium salt
  • p-(Di-n-propylsulfamyl)benzoic acid, sodium salt
  • p-(Dipropylsulfamoyl)benzoic acid, sodium salt
  • p-(Dipropylsulfamyl)benzoic acid, sodium salt
  • Probenecid sodium
  • Probenecid sodium salt
  • Sodium probenecid
  • UNII-FXB45Q4ZVK

Systematic Names

  • Benzoic acid, 4-((dipropylamino)sulfonyl)-, sodium salt (9CI)
  • Benzoic acid, p-(dipropylsulfamoyl)-, sodium salt

Registry Numbers

CAS Registry Number

  • 23795-03-1

FDA UNII

  • FXB45Q4ZVK

System Generated Number

  • 0023795031

Molecular Formulas

Molecular Formula

  • C13-H18-N-O4-S.Na

Molecular Formula Fragments

  • C13-H18-N-O4-S
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C13H19NO4S.Na/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16;/h5-8H,3-4,9-10H2,1-2H3,(H,15,16);/q;+1/p-1

InChIKey

QCCCFHDTBTUDEA-UHFFFAOYSA-M

Smiles

c1(S(N(CCC)CCC)(=O)=O)ccc(C(=O)[O-])cc1.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 270mg/kg (270mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: TETANY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
man TDLo oral 630mg/kg/6W (630mg/kg) KIDNEY, URETER, AND BLADDER: PROTEINURIS

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
Archives of Pathology. Vol. 94, Pg. 241, 1972.
mouse LD50 intravenous 458mg/kg (458mg/kg) BEHAVIORAL: TETANY

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
mouse LD50 oral 1666mg/kg (1666mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: TETANY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
mouse LD50 subcutaneous 1156mg/kg (1156mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: TETANY
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
rabbit LD50 intravenous 304mg/kg (304mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TETANY
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
rat LD50 intraperitoneal 394mg/kg (394mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TETANY

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
rat LD50 oral 1604mg/kg (1604mg/kg) BEHAVIORAL: TETANY

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.
rat LD50 subcutaneous 611mg/kg (611mg/kg) BEHAVIORAL: TETANY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 102, Pg. 208, 1951.