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Substance Name: 4-Aminopyrazolo(3,4-d)pyrimidine
RN: 2380-63-4
UNII: 0356MAT9LX
InChIKey: LHCPRYRLDOSKHK-UHFFFAOYSA-N

Note

  • Adenine analog which suppresses growth of E coli & Bacillus cereus; inhibits cell growth & purine biosynthesis in rat hepatoma.

Molecular Formula

  • C5-H5-N5

Molecular Weight

  • 135.1295
 

Classification Codes

  • Anti-Infective Agents
  • Anticholesteremic Agents
  • Antimetabolites
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Mutation Data
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Names and Synonyms

Name of Substance

  • 4-Aminopyrazolo(3,4-d)pyrimidine

Synonyms

  • 4 APP
  • 4-26-00-03541 (Beilstein Handbook Reference)
  • 4-Aminopyrazole(3,4-d)pyrimidine
  • 4-Aminopyrazolo(3,4-d)pyrimidine
  • 4-Aminopyrazolopyrimidine
  • 4-APP
  • AI3-52467
  • BRN 0005824
  • EINECS 219-174-6
  • NSC 1393
  • Pyrazoloadenine
  • UNII-0356MAT9LX

Systematic Names

  • 1H-Pyrazolo(3,4-d)pyrimidin-4-amine
  • 1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-

Registry Numbers

CAS Registry Number

  • 2380-63-4

FDA UNII

  • 0356MAT9LX

System Generated Number

  • 0002380634

Structure Descriptors

InChI

1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

InChIKey

LHCPRYRLDOSKHK-UHFFFAOYSA-N

Smiles

c1c2c(ncnc2[nH]n1)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 100mg/kg (100mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 398, 1956.
mouse LD10 unreported 15mg/kg (15mg/kg) LIVER: OTHER CHANGES Progress in Medical Chemistry. Vol. 7, Pg. 69, 1970.
mouse LD50 intraperitoneal 181mg/kg (181mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 oral 180mg/kg (180mg/kg) SENSE ORGANS AND SPECIAL SENSES: CILIARY SPASM: EYE

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 398, 1956.
rat LD50 intraperitoneal 228mg/kg (228mg/kg) SENSE ORGANS AND SPECIAL SENSES: CILIARY SPASM: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: EXCITEMENT
Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 398, 1956.
rat LD50 oral 141mg/kg (141mg/kg) SENSE ORGANS AND SPECIAL SENSES: CILIARY SPASM: EYE

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Proceedings of the Society for Experimental Biology and Medicine. Vol. 93, Pg. 398, 1956.