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Substance Name: Ambroxol Hydrochloride [JAN]
RN: 23828-92-4
UNII: CC995ZMV90
InChIKey: QNVKOSLOVOTXKF-PFWPSKEQSA-N

Note

  • A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

Molecular Formula

  • C13-H18-Br2-N2-O.Cl-H

Molecular Weight

  • 414.5671
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ambroxol Hydrochloride [JAN]

Synonyms

  • Ambroxol hydrochloride
  • Ambroxol lozenge
  • CCRIS 8686
  • EINECS 245-899-2
  • Mucoangin
  • Mucolear
  • Mucosolvan
  • NA 872 hydrochloride
  • trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride
  • UNII-CC995ZMV90

Systematic Names

  • Cyclohexanol, 4-(((2-amino-3,5-dibromophenyl)methyl)amino)-, monohydrochloride, trans- (9CI)
  • Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)-, hydrochloride, trans- (8CI)
  • Cyclohexanol, 4-(N-(2-amino-3,5-dibromobenzyl)amino)-, hydrochloride (E)-
  • trans-4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol hydrochloride

Registry Numbers

CAS Registry Number

  • 23828-92-4

FDA UNII

  • CC995ZMV90

Other Registry Number

  • 15942-05-9

System Generated Number

  • 0023828924

Molecular Formulas

Molecular Formula

  • C13-H18-Br2-N2-O.Cl-H

Molecular Formula Fragments

  • C13-H18-Br2-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChIKey

QNVKOSLOVOTXKF-PFWPSKEQSA-N

Smiles

Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 125mg/kg (125mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
dog LD50 oral 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig LD50 intraperitoneal 280mg/kg (280mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
guinea pig LD50 oral 1180mg/kg (1180mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse LD50 intraperitoneal 268mg/kg (268mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse LD50 intravenous 138mg/kg (138mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
mouse LD50 oral 2380mg/kg (2380mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
mouse LD50 subcutaneous 1060mg/kg (1060mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rabbit LD50 intravenous 64mg/kg (64mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit LD50 oral 2597mg/kg (2597mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM

GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rabbit LDLo intraperitoneal 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 889, 1978.
rat LD50 intraperitoneal 262mg/kg (262mg/kg) GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat LD50 intravenous 100mg/kg (100mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 281, 1981.
rat LD50 oral 4203mg/kg (4203mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.
rat LD50 subcutaneous 1489mg/kg (1489mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 263, 1981.