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Substance Name: Dexamethasone sodium phosphate [USP:BAN:JAN]
RN: 2392-39-4
UNII: AI9376Y64P
InChIKey: PLCQGRYPOISRTQ-FCJDYXGNSA-L

Classification Codes

  • Glucocorticoid
  • Hormone
  • Human Data
  • Reproductive Effect

Molecular Formulas

  • C22-H28-F-Na2-O8-P
  • C22-H30-F-O8-P.2Na

Molecular Weight

  • 516.4072
 
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Names and Synonyms

Name of Substance

  • Dexamethasone sodium phosphate [USP:BAN:JAN]

MeSH Heading

  • Dexamethasone 21-phosphate

Synonyms

  • 21-Disodium phosphate dexamethasone
  • 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt
  • Ak-Dex
  • Baldex
  • Colvasone
  • Corson
  • Dalalone
  • Decadron
  • Decadron Inhalation, Injection, Ophthalmic Solution and Ointment, and Topical Cream
  • Decadron phosphate
  • Decdan
  • Dexabene
  • Dexacort
  • Dexadreson
  • Dexagel
  • Dexagro
  • Dexaject SP
  • Dexamethasone 21-phosphate disodium salt
  • Dexamethasone disodium phosphate
  • Dexamethasone sodium phosphate
  • Dexamethasone-21-phosphate disodium salt
  • Dezone
  • Disodium dexamethasone phosphate
  • EINECS 219-243-0
  • Hexadrol
  • Hexadrol Injectable
  • Maxidex
  • Maxidex Ointment
  • Megacort
  • Onadron
  • Orgadrone
  • Sodium dexamethasone phosphate
  • Soldesam
  • Solu-Decadron
  • Spersadox
  • Turbinaire
  • UNII-AI9376Y64P

Systematic Names

  • Dexamethasone 21-(disodium phosphate)
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-(dihydrogen phosphate) disodium salt

Mixture Name

  • Neodecadron

Registry Numbers

CAS Registry Number

  • 2392-39-4

FDA UNII

  • AI9376Y64P

Other Registry Number

  • 55203-24-2

System Generated Number

  • 0002392394

Molecular Formulas

Molecular Formulas

  • C22-H28-F-Na2-O8-P
  • C22-H30-F-O8-P.2Na

Molecular Formula Fragments

  • C22-H30-F-O8-P
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChIKey

PLCQGRYPOISRTQ-FCJDYXGNSA-L

Smiles

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 1mg/kg (1mg/kg) GASTROINTESTINAL: PERITONITIS American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992.
infant TDLo intravenous 1500ug/kg/3D- (1.5mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS Lancet. Vol. 1, Pg. 632, 1987.
man TDLo intravenous 357ug/kg (0.357mg/kg) GASTROINTESTINAL: PERITONITIS American Journal of Emergency Medicine. Vol. 10, Pg. 268, 1992.
mouse LD50 intraperitoneal 550mg/kg (550mg/kg)   Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
mouse LD50 intravenous 932mg/kg (932mg/kg)   Drugs in Japan Vol. -, Pg. 785, 1995.
mouse LD50 oral 1800mg/kg (1800mg/kg)   Archives of Toxicology, Supplement. Vol. 7, Pg. 90, 1984.
women TDLo intravenous 320mg/kg (320mg/kg) GASTROINTESTINAL: OTHER CHANGES Lancet. Vol. 1, Pg. 1035, 1986.