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Substance Name: Tolnaftate [USAN:USP:INN:BAN:JAN]
RN: 2398-96-1
UNII: 06KB629TKV
InChIKey: FUSNMLFNXJSCDI-UHFFFAOYSA-N

Note

  • A synthetic antifungal agent.

Molecular Formula

  • C19-H17-N-O-S

Molecular Weight

  • 307.4153
 

Classification Codes

  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Tolnaftate
  • Tolnaftate [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Tolnaftate

Synonyms

  • 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
  • Aftate
  • BRN 2752620
  • Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester
  • Chinofungin
  • Dermoxin
  • Dr. Scholl's Athlete's Foot Spray
  • EINECS 219-266-6
  • Focusan
  • Fungistop
  • HI-Alazin
  • m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
  • Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
  • Naphthiomate T
  • NSC 233648
  • O-2-Naphthyl m,N-dimethylthiocarbanilate
  • Phytoderm
  • Pitrex
  • Sch 10144
  • Sorgoa
  • Sporiline
  • Timoped
  • Tinactin
  • Tinaderm
  • Tinavet
  • Tolnaftate
  • Tolnaftato
  • Tolnaftato [DCIT]
  • Tolnaftato [INN-Spanish]
  • Tolnaftatum
  • Tolnaftatum [INN-Latin]
  • Tolnaphthate
  • Tolsanil
  • Tonoftal
  • Tritin
  • UNII-06KB629TKV

Systematic Names

  • Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester
  • Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-2-naphthalenyl ester
  • Carbanilic acid, m,N-dimethylthio-, O-2-naphthyl ester
  • Tolnaftate

Mixture Name

  • Tinavet (Veterinary)

Registry Numbers

CAS Registry Number

  • 2398-96-1

FDA UNII

  • 06KB629TKV

Other Registry Number

  • 94256-64-1

System Generated Number

  • 0002398961

Structure Descriptors

InChI

1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3

InChIKey

FUSNMLFNXJSCDI-UHFFFAOYSA-N

Smiles

c12c(cc(OC(N(c3cc(ccc3)C)C)=S)cc1)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 14gm/kg (14000mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 615, 1964.
guinea pig LD50 oral > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg)   Drug and Chemical Toxicology. Vol. 13, Pg. 195, 1990.
mouse LD50 intravenous 4800mg/kg (4800mg/kg)   Drugs in Japan Vol. 6, Pg. 530, 1982.
mouse LD50 oral 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 530, 1982.
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rabbit LD intravenous > 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rat LD50 oral > 6gm/kg (6000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 380, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 111 deg C   EXP
log P (octanol-water) 5.810 (none)   EST
Atmospheric OH Rate Constant 4.01E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.