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Substance Name: Cloxazolam [INN:JAN]
RN: 24166-13-0
UNII: GYL649Z0HY
InChIKey: ZIXNZOBDFKSQTC-UHFFFAOYSA-N

Note

  • Analog of oxazolam.

Molecular Formula

  • C17-H14-Cl2-N2-O2

Molecular Weight

  • 349.2156
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Cloxazolam
  • Cloxazolam [INN:JAN]

Synonyms

  • 10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo(3,2-d) (1,4)benzodiazepin-6(5H)-one
  • Betavel
  • BRN 0569691
  • Cloxam
  • Cloxazolam
  • Cloxazolamum
  • Cloxazolamum [INN-Latin]
  • Cloxazolazepam
  • CS 370
  • Enadel
  • Lubalix
  • MT 14-411
  • Olcadil
  • Sepazon
  • Tolestan
  • UNII-GYL649Z0HY

Systematic Names

  • 10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo(3,2-d) (1,4)benzodiazepin-6(5H)-one
  • 10-Chloro-2,3,5,6,7,11b-hexahydro-11b-(o-chlorophenyl)benzo(6,7)-1,4-diazepino-(5,4-b)-oxazol-6-one
  • Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-

Superlist Names

  • Cloxazolam
  • DEA No. 2753

Registry Numbers

CAS Registry Number

  • 24166-13-0

FDA UNII

  • GYL649Z0HY

System Generated Number

  • 0024166130

Structure Descriptors

InChI

1S/C17H14Cl2N2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

InChIKey

ZIXNZOBDFKSQTC-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)C23c4cc(ccc4NC(=O)CN2CCO3)Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6gm/kg (6000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 oral 2630mg/kg (2630mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 subcutaneous > 6gm/kg (6000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 intraperitoneal 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 1780mg/kg (1780mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 203 dec deg C   EXP
log P (octanol-water) 3.910 (none)   EST
Atmospheric OH Rate Constant 4.38E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.