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Substance Name: Econazole nitrate [USAN:USP:BAN:JAN]
RN: 24169-02-6
UNII: H438WYN10E
InChIKey: DDXORDQKGIZAME-UHFFFAOYSA-N

Note

  • A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Molecular Formula

  • C18-H15-Cl3-N2-O x H-N-O3

Molecular Weight

  • 444.7004
 

Classification Codes

  • Antifungal
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • Econazole nitrate [USAN:USP:BAN:JAN]

Synonyms

  • (+-)-Econazole nitrate
  • 1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate
  • 1-(2-((4-Chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
  • CCRIS 6031
  • Econazole mononitrate
  • Econazole nitrate
  • Ecoza
  • EINECS 246-053-5
  • epi-Pevaryl
  • Gyno-pevaryl
  • Gyno-Pevaryl 150
  • Ifenec
  • Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-, mononitrate
  • NSC 243115
  • Pevaryl
  • R 14,827
  • R 14827
  • Spectazole
  • SQ 13050
  • UNII-H438WYN10E

Systematic Names

  • 1-(2-((4-Chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazolium nitrate
  • 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, mononitrate
  • 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, mononitrate (9CI)
  • 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, nitrate
  • Econazole nitrate
  • Imidazole, 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)-, mononitrate (8CI)

Mixture Name

  • EcoNail

Registry Numbers

CAS Registry Number

  • 24169-02-6

FDA UNII

  • H438WYN10E

Other Registry Number

  • 68797-31-9

Related Registry Number

  • 27220-47-9 (Parent)

System Generated Number

  • 0024169026

Molecular Formulas

Molecular Formula

  • C18-H15-Cl3-N2-O x H-N-O3

Molecular Formula Fragments

  • C18-H15-Cl3-N2-O
  • H-N-O3

Structure Descriptors

InChI

1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)

InChIKey

DDXORDQKGIZAME-UHFFFAOYSA-N

Smiles

O[N+](=O)[O-].Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 224, 1975.
guinea pig LD50 oral 272mg/kg (272mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 224, 1975.
mouse LD50 intraperitoneal 180mg/kg (180mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
mouse LD50 intravenous 38mg/kg (38mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
mouse LD50 oral 463mg/kg (463mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 224, 1975.
mouse LD50 subcutaneous 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
rabbit LD50 intravenous 85mg/kg (85mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
rabbit LD50 oral 431mg/kg (431mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 1253, 1981.
rabbit LD50 subcutaneous 650mg/kg (650mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
rat LD50 intraperitoneal 240mg/kg (240mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
rat LD50 intravenous 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.
rat LD50 oral 668mg/kg (668mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 224, 1975.
rat LD50 subcutaneous 1360mg/kg (1360mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 643, 1978.