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Substance Name: Mianserin [INN:BAN]
RN: 24219-97-4
UNII: 250PJI13LM
InChIKey: UEQUQVLFIPOEMF-UHFFFAOYSA-N

Note

  • A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.

Molecular Formula

  • C18-H20-N2

Molecular Weight

  • 264.37
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Human Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Serotonin Agents
  • Serotonin Antagonists
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Names and Synonyms

Results Name

  • Mianserin [INN:BAN]

Name of Substance

  • Mianserin
  • Mianserin [INN:BAN]

MeSH Heading

  • Mianserin

Synonyms

  • 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine
  • BRN 0755346
  • EINECS 246-088-6
  • HSDB 7182
  • Mianserin
  • Mianserina
  • Mianserina [INN-Spanish]
  • Mianserine
  • Mianserine [INN-French]
  • Mianserinum
  • Mianserinum [INN-Latin]
  • Mianseryna
  • Mianseryna [Polish]
  • UNII-250PJI13LM

Systematic Names

  • Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-
  • Mianserin

Registry Numbers

CAS Registry Number

  • 24219-97-4

FDA UNII

  • 250PJI13LM

Related Registry Number

  • 21535-47-7 (mono-hydrochloride)

System Generated Number

  • 0024219974

Structure Descriptors

InChI

1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3

InChIKey

UEQUQVLFIPOEMF-UHFFFAOYSA-N

Smiles

CN1CCN2c3ccccc3Cc4ccccc4C2C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 9mg/kg/3W-I (9mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: OTHER CHANGES
Medical Journal of Australia. Vol. 140, Pg. 166, 1984.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 40, Pg. 235, 1983.
mouse LD50 oral 365mg/kg (365mg/kg)   Drug Development Research. Vol. 3, Pg. 357, 1983.
rat LD50 oral 925mg/kg (925mg/kg)   Journal of International Medical Research. Vol. 13, Pg. 77, 1985.
women TDLo oral 1200ug/kg (1.2mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: CHANGE IN RATE
Human & Experimental Toxicology. Vol. 10, Pg. 383, 1991.
women TDLo oral 25mg/kg/6W-I (25mg/kg) BLOOD: AGRANULOCYTOSIS British Medical Journal. Vol. 291, Pg. 1375, 1985.
women TDLo oral 876mg/kg/2Y-I (876mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: GENERAL ANESTHETIC
Italian Journal of Neurological Sciences. Vol. 9, Pg. 167, 1988.