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Substance Name: Dexchlorpheniramine maleate [USP]
RN: 2438-32-6
UNII: B10YD955QW
InChIKey: DBAKFASWICGISY-DASCVMRKSA-N

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent

Molecular Formula

  • C16-H19-Cl-N2.C4-H4-O4

Molecular Weight

  • 390.865
 
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Names and Synonyms

Name of Substance

  • Dexchlorpheniramine maleate [USP]

Synonyms

  • (+)-2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
  • (+)-Chlorpheniramine maleate
  • Chlorpheniramine d-form maleate
  • d-Chlorpheniramine maleate
  • Dexchloropheniramine maleate
  • Dexchlorpheniramine maleate
  • Dextrochlorpheniramine maleate
  • EINECS 219-450-6
  • Mylaramine
  • Polaramine
  • S-(+)-Chlorpheniramine maleate
  • UNII-B10YD955QW

Systematic Names

  • (gamma-(4-Chlorophenyl)-pyridine-2-propyl)(dimethyl)ammonium hydrogen (Z)-maleate
  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)-, (Z)-2-butenedioate (1:1)
  • Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1), (+)-

Mixture Names

  • Polaramine Expectorant
  • Rescon JR
  • Rescon MX

Registry Numbers

CAS Registry Number

  • 2438-32-6

FDA UNII

  • B10YD955QW

Other Registry Number

  • 19141-42-5

System Generated Number

  • 0002438326

Molecular Formulas

Molecular Formula

  • C16-H19-Cl-N2.C4-H4-O4

Molecular Formula Fragments

  • C16-H19-Cl-N2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

InChIKey

DBAKFASWICGISY-DASCVMRKSA-N

Smiles

CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 240mg/kg (240mg/kg) BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 124, Pg. 347, 1958.
mouse LD50 intraperitoneal 82mg/kg (82mg/kg)   Drugs in Japan Vol. -, Pg. 436, 1995.
mouse LD50 intravenous 20mg/kg (20mg/kg)   Drugs in Japan Vol. -, Pg. 436, 1995.
mouse LD50 oral 133mg/kg (133mg/kg)   Drugs in Japan Vol. -, Pg. 436, 1995.
rat LD50 intraperitoneal 84mg/kg (84mg/kg)   Drugs in Japan Vol. -, Pg. 436, 1995.
rat LD50 oral 188mg/kg (188mg/kg)   Drugs in Japan Vol. -, Pg. 436, 1995.