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Substance Name: Bufexamac [INN:BAN:DCF:JAN]
RN: 2438-72-4
UNII: 4T3C38J78L
InChIKey: MXJWRABVEGLYDG-UHFFFAOYSA-N

Note

  • A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally.

Molecular Formula

  • C12-H17-N-O3

Molecular Weight

  • 223.27
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Bufexamac
  • Bufexamac [INN:BAN:DCF:JAN]

MeSH Heading

  • Bufexamac

Synonyms

  • 4-Butoxy-N-hydroxybenzeneacetamide
  • 4-Butoxyphenylacetohydroxamic acid
  • Acide p-butoxyphenylacethydroxamique
  • Acide p-butoxyphenylacethydroxamique [French]
  • Anderm
  • BRN 2646848
  • Bufessamac
  • Bufessamac [DCIT]
  • Bufexamac
  • Bufexamaco
  • Bufexamaco [INN-Spanish]
  • Bufexamacum
  • Bufexamacum [INN-Latin]
  • Bufexamic acid
  • CP 1044
  • CP 1044 J3
  • Droxaryl
  • EINECS 219-451-1
  • Feximac
  • Flogicid
  • Flogocid N plastigel
  • J3
  • Malipuran
  • Mofenar
  • Norfemac
  • p-Butoxyphenylacetohydroxamic acid
  • Paraderm
  • Parfenac
  • Parfenal
  • UNII-4T3C38J78L

Systematic Names

  • 2-(p-Butoxyphenyl)-acetohydroxamic acid
  • Acetohydroxamic acid, 2-(p-butoxyphenyl)-
  • Benzeneacetamide, 4-butoxy-N-hydroxy- (9CI)
  • Bufexamac

Registry Numbers

CAS Registry Number

  • 2438-72-4

FDA UNII

  • 4T3C38J78L

System Generated Number

  • 0002438724

Structure Descriptors

InChI

1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

InChIKey

MXJWRABVEGLYDG-UHFFFAOYSA-N

Smiles

c1c(ccc(c1)CC(NO)=O)OCCCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1195mg/kg (1195mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.
mouse LD50 oral 8gm/kg (8000mg/kg)   Journal of Medicinal Chemistry. Vol. 13, Pg. 211, 1970.
mouse LD50 skin > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.
rat LD50 intraperitoneal 805mg/kg (805mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.
rat LD50 oral 3370mg/kg (3370mg/kg)   Drugs in Japan Vol. 6, Pg. 681, 1982.
rat LD50 skin > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakkyoku. Pharmacy. Vol. 28, Pg. 253, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 154 deg C   EXP
log P (octanol-water) 2.08 (none)   EXP
Water Solubility 554 mg/L 25 EST
Vapor Pressure 2.44E-09 mm Hg 25 EST
Henry's Law Constant 2.50E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.47E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.