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Substance Name: Sulfadoxine [USAN:USP:INN:BAN:JAN]
RN: 2447-57-6
UNII: 88463U4SM5
InChIKey: PJSFRIWCGOHTNF-UHFFFAOYSA-N
Note
- A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Molecular Formula
- C12-H14-N4-O4-S
Molecular Weight
- 310.3326
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Infective Agents
- Anti-Infective Agents, Urinary
- Antibacterial
- Antimalarials
- Antiparasitic Agents
- Antiprotozoal Agents
- Drug / Therapeutic Agent
- Renal Agents
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Names and Synonyms
Name of Substance
- Sulfadoxine
- Sulfadoxine [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Sulfadoxine
Synonyms
- 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- 4-Sulfanilamido-5,6-dimethoxypyrimidine
- 5-25-13-00306 (Beilstein Handbook Reference)
- 6-(4-Aminobenzenesulfonamido)-4,5-dimethoxypyrimidine
- BRN 0625453
- EINECS 219-504-9
- Fanasil
- Fanzil
- N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide
- N(sup 1)-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
- N1-(5,6-Dimethoxy-4-pyrimidinyl)sulfanilamide
- Ro 4-4393
- Solfadossina
- Solfadossina [DCIT]
- Sulfadoxina
- Sulfadoxina [INN-Spanish]
- Sulfadoxine
- Sulfadoxinum
- Sulfadoxinum [INN-Latin]
- Sulforthomidine
- Sulphadoxine
- Sulphormethoxine
- UNII-88463U4SM5
- WR 4873
Systematic Names
- Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-
- Sulfadoxine
Mixture Name
- Fansidar
Registry Numbers
CAS Registry Number
- 2447-57-6
FDA UNII
- 88463U4SM5
System Generated Number
- 0002447576
Structure Descriptors
InChI
InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)InChIKey
PJSFRIWCGOHTNF-UHFFFAOYSA-NSmiles
COc1ncnc(NS(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 60mg/kg (60mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Chemotherapy Vol. 14, Pg. 37, 1969. |
| mouse | LD50 | intraperitoneal | 2900mg/kg (2900mg/kg) | Chemotherapy Vol. 14, Pg. 195, 1969. | |
| mouse | LD50 | oral | 5200mg/kg (5200mg/kg) | Chemotherapy Vol. 14, Pg. 195, 1969. | |
| mouse | LD50 | subcutaneous | 2900mg/kg (2900mg/kg) | Chemotherapy Vol. 14, Pg. 195, 1969. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 190-194 | deg C | EXP | |
| log P (octanol-water) | 0.7 | (none) | EXP | |
| Water Solubility | 2700 | mg/L | 25 | EST |
| Vapor Pressure | 1.59E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.42E-15 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.83E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.