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Substance Name: Dapivirine [USAN:INN]
RN: 244767-67-7
UNII: TCN4MG2VXS
InChIKey: ILAYIAGXTHKHNT-UHFFFAOYSA-N

Note

  • Effectively prevented human immunodeficiency virus (HIV) infection in cocultures of monocyte-derived dendritic cells and T cells, representing primary targets in sexual transmission.

Molecular Formula

  • C20-H19-N5

Molecular Weight

  • 329.405
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
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Names and Synonyms

Name of Substance

  • Dapivirine
  • Dapivirine [USAN:INN]

Synonyms

  • 4-((4-((2,4,6-Trimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile
  • Dapivirine
  • Dapivirine intravaginal ring
  • R 147681
  • R-147681
  • R147681
  • Ring-004
  • TMC 120
  • TMC-120
  • TMC120
  • TMC120-R147681
  • UNII-TCN4MG2VXS

Systematic Name

  • 4-((4-((2,4,6-Trimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile

Registry Numbers

CAS Registry Number

  • 244767-67-7

FDA UNII

  • TCN4MG2VXS

System Generated Number

  • 0244767677

Structure Descriptors

InChI

InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)

InChIKey

ILAYIAGXTHKHNT-UHFFFAOYSA-N

Smiles

Cc1cc(C)c(Nc2ccnc(Nc3ccc(cc3)C#N)n2)c(C)c1