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Substance Name: Dexrazoxane [USAN:INN:BAN]
RN: 24584-09-6
UNII: 048L81261F
InChIKey: BMKDZUISNHGIBY-ZETCQYMHSA-N

Note

  • The (+)-enantiomorph of razoxane.

Molecular Formula

  • C11-H16-N4-O4

Molecular Weight

  • 268.271
 

Classification Codes

  • Antineoplastic Agents
  • Cardioprotectant
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Immunosuppressive Agents
  • Mutation Data
  • Protective Agents
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Names and Synonyms

Name of Substance

  • Dexrazoxane
  • Dexrazoxane [USAN:INN:BAN]

MeSH Heading

  • Dexrazoxane

Synonyms

  • (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione
  • (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)-
  • ADR 529
  • ADR-529
  • BRN 5759131
  • Cardioxane
  • CCRIS 9394
  • Dexrazoxane
  • Dexrazoxano
  • Dexrazoxano [INN-Spanish]
  • Dexrazoxanum
  • Dexrazoxanum [INN-Latin]
  • HSDB 7319
  • ICRF 187
  • ICRF-187
  • NSC 169780
  • UNII-048L81261F
  • Zinecard

Systematic Names

  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)- (9CI)
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-
  • 2,6-Piperazinedione, 4,4'-propylenedi-, (+)-

Registry Numbers

CAS Registry Number

  • 24584-09-6

FDA UNII

  • 048L81261F

System Generated Number

  • 0024584096

Structure Descriptors

InChI

1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1

InChIKey

BMKDZUISNHGIBY-ZETCQYMHSA-N

Smiles

N1C(CN(CC1=O)C[C@@H](N1CC(NC(C1)=O)=O)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 2gm/kg (2000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Cancer Treatment Reports. Vol. 64, Pg. 1211, 1980.
man TDLo intravenous 383mg/kg (383mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LIVER: LIVER FUNCTION TESTS IMPAIRED

BLOOD: LEUKOPENIA
Cancer Clinical Trials. Vol. 4, Pg. 143, 1981.
mouse LD10 intraperitoneal 500mg/kg (500mg/kg)   Cancer Chemotherapy and Pharmacology. Vol. 38, Pg. 203, 1996.