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Substance Name: Fominoben hydrochloride [JAN]
RN: 24600-36-0
UNII: XCT2R4OS1G
InChIKey: ZAOHKACVOFGZOI-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C21-H24-Cl-N3-O3.Cl-H

Molecular Weight

  • 438.3525
 
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Names and Synonyms

Name of Substance

  • Fominoben hydrochloride
  • Fominoben hydrochloride [JAN]

Synonyms

  • 3'-Chloro-2'-(N-methyl-N-((morpholinocarbonyl)methyl)aminomethyl)benzanilide hydrochloride
  • 3'-Chloro-alpha-(methyl((morpholinocarbonyl)methyl)amino)-o-benzotoluidide hydrochloride
  • 3'-Chloro-beta-(N-methyl-N-((morpholinocarbonyl)methyl)aminomethyl)benzanilide hydrochloride
  • Deronyl hydrochloride
  • EINECS 246-344-7
  • Finaten
  • Fominoben HCl
  • Fominoben hydrochloride
  • Noleptan
  • NSC 293901
  • Oleptan
  • PB 89
  • PB 89 chloride
  • PB 89CL
  • PB-89 hydrochloride
  • Terion
  • Tussirama
  • UNII-XCT2R4OS1G

Systematic Names

  • Benzamide, N-(3-chloro-2-((methyl(2-(4-morpholinyl)-2-oxoethyl)amino)methyl)phenyl)-, monohydrochloride (9CI)
  • N-(3-Chloro-2-((methyl(2-morpholino-2-oxoethyl)amino)methyl)phenyl)benzamide monohydrochloride
  • o-Benzotoluidide, 3'-chloro-alpha-(methyl((morpholinocarbonyl)methyl)amino)-, hydrochloride
  • o-Benzotoluidide, 3'-chloro-alpha-(methyl((morpholinocarbonyl)methyl)amino)-, monohydrochloride (8CI)

Registry Numbers

CAS Registry Number

  • 24600-36-0

FDA UNII

  • XCT2R4OS1G

System Generated Number

  • 0024600360

Molecular Formulas

Molecular Formula

  • C21-H24-Cl-N3-O3.Cl-H

Molecular Formula Fragments

  • C21-H24-Cl-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H24ClN3O3.ClH/c1-24(15-20(26)25-10-12-28-13-11-25)14-17-18(22)8-5-9-19(17)23-21(27)16-6-3-2-4-7-16;/h2-9H,10-15H2,1H3,(H,23,27);1H

InChIKey

ZAOHKACVOFGZOI-UHFFFAOYSA-N

Smiles

c1(c(NC(=O)c2ccccc2)cccc1Cl)CN(CC(=O)[N+]1CCOCC1)C.[Cl-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 300mg/kg (300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
dog LD50 oral 3300mg/kg (3300mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
guinea pig LD50 intraperitoneal 810mg/kg (810mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 296, 1973.
guinea pig LD50 oral 2113mg/kg (2113mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 296, 1973.
mouse LD50 intraperitoneal 630mg/kg (630mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 296, 1973.
mouse LD50 intravenous 130mg/kg (130mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
mouse LD50 oral 2200mg/kg (2200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 296, 1973.
mouse LD50 subcutaneous 1770mg/kg (1770mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1491, 1974.
rabbit LD50 oral 4800mg/kg (4800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 736, 1978.
rat LD50 intraperitoneal 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rat LD50 intravenous 57mg/kg (57mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rat LD50 oral 4200mg/kg (4200mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 736, 1978.
rat LD50 subcutaneous 8700mg/kg (8700mg/kg)   Drugs in Japan Vol. -, Pg. 1121, 1990.