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Substance Name: Nifurpipone [INN]
RN: 24632-47-1
UNII: G7274CK635
InChIKey: FHHFNHFFCVLLHX-MDWZMJQESA-N

Classification Codes

  • Chemotherapeutic
  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C12-H17-N5-O4

Molecular Weight

  • 295.2973
 
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Names and Synonyms

Name of Substance

  • Nifurpipone
  • Nifurpipone [INN]

Synonyms

  • 1-Piperazineacetic acid, 4-methyl-, ((5-nitro-2-furanyl)methylene)hydrazide
  • 2-(4-Methyl-1-piperazinyl)-N'-(5-nitrofurfuryliden)acetohydrazid
  • 2-Furaldehyde, 5-nitro-, (4-methylpiperazinylacetyl)hydrazone
  • 4-Methyl-1-piperazineacetic acid (5-nitrofurfurylidene)hydrazide
  • 4-Methyl-piperazino-acetohydrazone-5-nitrofurfurol
  • 5-Nitro-2-furaldehyde 4-methylpiperazinoacethydrazone
  • 5-Nitro-2-furaldehyde N'-methylpiperazinoacethydrazone
  • 5-Nitro-2-furfuraldehyde-N'-methyl-N-piperazinoacethydrazone
  • BRN 0896107
  • Nifurpipona
  • Nifurpipona [INN-Spanish]
  • Nifurpipone
  • Nifurpiponum
  • Nifurpiponum [INN-Latin]
  • NP
  • NSC 276014
  • Rec 15 0122
  • UNII-G7274CK635

Systematic Names

  • 1-Piperazineacetic acid, 4-methyl-, ((5-nitro-2-furanyl)methylene)hydrazide (9CI)
  • 1-Piperazineacetic acid, 4-methyl-, (5-nitrofurfurylidene)hydrazide
  • 4-Methyl-1-piperazineacetic acid (5-nitrofurfurylidene)hydrazide

Registry Numbers

CAS Registry Number

  • 24632-47-1

FDA UNII

  • G7274CK635

Related Registry Numbers

  • 24632-48-2 (di-hydrochloride)
  • 51799-29-2 (acetate)
  • 51799-31-6 (unspecified maleate)
  • 56217-89-1 (mono-hydrochloride)
  • 56217-90-4 (maleate[1:1])

System Generated Number

  • 0024632471

Structure Descriptors

InChI

1S/C12H17N5O4/c1-15-4-6-16(7-5-15)9-11(18)14-13-8-10-2-3-12(21-10)17(19)20/h2-3,8H,4-7,9H2,1H3,(H,14,18)/b13-8+

InChIKey

FHHFNHFFCVLLHX-MDWZMJQESA-N

Smiles

CN1CCN(CC1)CC(=O)N/N=C/c2ccc(o2)[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 315mg/kg (315mg/kg)   Journal of Medicinal Chemistry. Vol. 14, Pg. 633, 1971.
mouse LD50 intravenous 295mg/kg (295mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 14(7), Pg. 1317, 1972.
mouse LD50 oral 880mg/kg (880mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Bollettino Chimico Farmaceutico. Vol. 114, Pg. 73, 1975.
rabbit LD50 oral 400mg/kg (400mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 14(7), Pg. 1317, 1972.
rat LD50 intraperitoneal 212mg/kg (212mg/kg)   Bollettino Chimico Farmaceutico. Vol. 114, Pg. 73, 1975.
rat LD50 oral 990mg/kg (990mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Bollettino Chimico Farmaceutico. Vol. 114, Pg. 73, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.1 (none)   EXP
Water Solubility 318 mg/L 25 EST
Vapor Pressure 3.64E-09 mm Hg 25 EST
Henry's Law Constant 2.73E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.02E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.