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Substance Name: Dibotermin alfa [USAN:INN:BAN]
RN: 246539-15-1
UNII: T472P45MG6


  • A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.

Molecular Formula

  • Unspecified

Molecular Weight

  • 14881.0164

Classification Codes

  • Growth Factor
  • Osteoinductive Agent for use in Orthopaedic Surgery, Dental/Craniofacial Surgery, or Spine Surgery, as an Adjunct to Standard Care Oras a Replacement for Autogenous Bone Graft
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Names and Synonyms

Name of Substance

  • Dibotermin alfa [USAN:INN:BAN]
  • Recombinant human bone morphogenetic protein-2


  • BMP 2
  • BMP-2
  • Bone morphogenetic protein 2
  • Bone morphogenetic protein 2 (human recombinant rhBMP-2). Dibotermin alfa is a glycosylated (oligomannosidic), disulfide-linked dimeric protein consisting of all combinations of the two N-terminal processed subunits. The N-terminal glutamine may also exist as pyroglutamic acid, as a result of spontaneous cyclization of N-terminal glutamine to pyroglutamate. Molecular weights are approximately 28,000 to 33,000 daltons (dimer) or 14,000 to 17,000 daltons (monomer)
  • Dibotermin alfa
  • InductOs
  • rhBMP-2
  • UNII-T472P45MG6

Systematic Name

  • Bone morphogenetic protein 2 (human recombinant rhBMP-2)

Mixture Names

  • Amplify [Bone Graft]
  • Infuse [Bone Graft]

Registry Numbers

CAS Registry Number

  • 246539-15-1


  • T472P45MG6

System Generated Number

  • 0246539151