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Substance Name: Senegenin
RN: 2469-34-3
UNII: 06S1QH951L
InChIKey: CWHJIJJSDGEHNS-MYLFLSLOSA-N

Note

  • Decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells.

Molecular Formula

  • C30-H45-Cl-O6

Molecular Weight

  • 537.1325
 
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Names and Synonyms

Name of Substance

  • Senegenin

Synonyms

  • 3-10-00-02482 (Beilstein Handbook Reference)
  • BRN 2714357
  • Senegenin
  • Senegin
  • UNII-06S1QH951L

Systematic Name

  • 27-Noro-13-ene-23,28-dioic acid, 12-(chloromethyl)-2-beta,3-beta-dihydroxy-

Registry Numbers

CAS Registry Number

  • 2469-34-3

FDA UNII

  • 06S1QH951L

System Generated Number

  • 0002469343

Structure Descriptors

InChI

1S/C30H45ClO6/c1-26(2)10-11-30(25(36)37)9-6-17-22(18(30)13-26)16(15-31)12-21-27(17,3)8-7-20-28(21,4)14-19(32)23(33)29(20,5)24(34)35/h16,18-21,23,32-33H,6-15H2,1-5H3,(H,34,35)(H,36,37)/t16-,18+,19+,20-,21+,23+,27+,28+,29+,30-/m1/s1

InChIKey

CWHJIJJSDGEHNS-MYLFLSLOSA-N

Smiles

CC1(C)CC[C@@]2(CCC3=C([C@@H](CCl)C[C@@H]4[C@@]5(C)C[C@H](O)[C@H](O)[C@](C)([C@@H]5CC[C@@]34C)C(=O)O)[C@@H]2C1)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3mg/kg (3mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(2), Pg. 259, 1982.
mouse LDLo intravenous 45mg/kg (45mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse LDLo oral 1gm/kg (1000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse LDLo subcutaneous 30mg/kg (30mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.