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Substance Name: Azaphen
RN: 24853-80-3
UNII: MFB4TD413U
InChIKey: ZZVWCKAYZSAUKR-UHFFFAOYSA-N

Note

  • Antidepressant with a tricyclic structure may affect the autonomic nervous system; don't confuse with AZOPHEN, a brand name for ANTIPYRINE.

Molecular Formula

  • C16-H19-N5-O.2Cl-H

Molecular Weight

  • 370.282
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Azaphen

Synonyms

  • 2-(4-Methyl-1-piperazinyl)-10-methyl-3,4-diazaphenoxazindihydrochlorid
  • 2-(4-Methyl-1-piperazinyl)-10-methyl-3,4-diazaphenoxazindihydrochlorid [German]
  • 5-Methyl-3-(4-methyl-1-piperazinyl)-5H-pyridazino(3,4-b)(1,4)benzoxazine dihydrochloride
  • Azafen
  • Azaphen
  • Azaphen hydrochloride
  • UNII-MFB4TD413U

Systematic Name

  • 5H-Pyridazino(3,4-b)(1,4)benzoxazine, 5-methyl-3-(4-methyl-1-piperazinyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 24853-80-3

FDA UNII

  • MFB4TD413U

System Generated Number

  • 0024853803

Molecular Formulas

Molecular Formula

  • C16-H19-N5-O.2Cl-H

Molecular Formula Fragments

  • C16-H19-N5-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H19N5O.2ClH/c1-19-7-9-21(10-8-19)15-11-13-16(18-17-15)22-14-6-4-3-5-12(14)20(13)2;;/h3-6,11H,7-10H2,1-2H3;2*1H

InChIKey

ZZVWCKAYZSAUKR-UHFFFAOYSA-N

Smiles

O1c2c(N(c3cc(nnc13)N1CCN(CC1)C)C)cccc2.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 200mg/kg (200mg/kg)   Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975.
mouse LD50 intravenous 63mg/kg (63mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Russian Pharmacology and Toxicology Vol. 37, Pg. 2, 1974.
mouse LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: WAKEFULNESS Pharmaceutical Chemistry Journal Vol. 4, Pg. 118, 1970.
mouse LD50 subcutaneous 330mg/kg (330mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975.
rat LD50 intravenous 48mg/kg (48mg/kg)   Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975.
rat LD50 oral 1gm/kg (1000mg/kg)   Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975.
rat LD50 subcutaneous 490mg/kg (490mg/kg)   Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975.