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Substance Name: Spiramycin III
RN: 24916-52-7
UNII: 0NHE9TRJ93
InChIKey: HSZLKTCKAYXVBX-DCAGQSADSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C46-H78-N2-O15

Molecular Weight

  • 899.121
 
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Names and Synonyms

Name of Substance

  • Spiramycin III

Synonyms

  • Foromacidin C
  • Foromacidine C
  • Spiramycin 3
  • Spiramycin III
  • UNII-0NHE9TRJ93

Systematic Names

  • Leucomycin V, 9-O-((2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)-, 3-propanoate
  • Leucomycin V, 9-O-(5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)-, 3-propanoate, (9(2R,5S,6R))-
  • Spiramycin C

Registry Numbers

CAS Registry Number

  • 24916-52-7

FDA UNII

  • 0NHE9TRJ93

Other Registry Numbers

  • 11001-07-3
  • 13429-99-7
  • 13441-33-3
  • 13445-44-8
  • 1403-59-4
  • 1405-27-2
  • 203005-19-0
  • 23410-82-4
  • 33299-71-7

System Generated Number

  • 0024916527

Structure Descriptors

InChI

1S/C46H78N2O15/c1-13-35(50)60-34-24-36(51)56-27(3)17-15-14-16-18-33(61-37-20-19-32(47(8)9)28(4)57-37)26(2)23-31(21-22-49)42(43(34)55-12)63-45-40(52)39(48(10)11)41(29(5)59-45)62-38-25-46(7,54)44(53)30(6)58-38/h14-16,18,22,26-34,37-45,52-54H,13,17,19-21,23-25H2,1-12H3/b15-14+,18-16+/t26-,27-,28+,29-,30+,31+,32+,33+,34-,37+,38+,39-,40-,41-,42+,43+,44+,45+,46-/m1/s1

InChIKey

HSZLKTCKAYXVBX-DCAGQSADSA-N

Smiles

O1[C@H](CC[C@@H]([C@@H]1C)N(C)C)O[C@@H]1[C@@H](C[C@@H]([C@@H]([C@@H](OC)[C@@H](CC(O[C@H](C)CC=CC=C1)=O)OC(=O)CC)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)N(C)C)O[C@@H]1O[C@H]([C@@H]([C@@](C1)(O)C)O)C)C)CC=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 407mg/kg (407mg/kg)   Antibiotics and Chemotherapy Vol. 11, Pg. 652, 1961.
mouse LD50 intravenous 204mg/kg (204mg/kg)   Antibiotics and Chemotherapy Vol. 11, Pg. 652, 1961.
mouse LD50 subcutaneous 2040mg/kg (2040mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 606, 1967.