Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Poly I-C
RN: 24939-03-5

Note

  • Interferon inducer consisting of a synthetic, mismatched double-stranded RNA. The polymer is made of one strand each of polyinosinic acid and polycytidylic acid.

Molecular Formula

  • (C10-H13-N4-O8-P)x-.(C9-H14-N3-O8-P)x-

Molecular Weight

  • 671.4033
 

Classification Codes

  • Anti-Infective Agents
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Interferon Inducers
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
* denotes mobile formatted website

Links to Resources

Names and Synonyms

Name of Substance

  • Poly I-C

MeSH Heading

  • Poly I-C

Synonyms

  • 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1)
  • NSC 123233
  • NSC-120949
  • PI:C
  • Poly C poly I
  • Poly I:poly C
  • Poly IC
  • Poly rI:poly rC
  • Poly(cytidylic acid)-poly(inosinic acid)
  • Poly(I).poly(C)
  • Poly(I).poly(C) complex
  • Poly(I).poly(C); Poly(I).poly(C) complex
  • Poly(I+C)
  • Poly(I:C) (VAN)
  • Poly(rI).(rC)
  • Poly(rI).poly(rC)
  • Polycytidylic-polyinosinic acid
  • Polyinosinate-polycytidylate complex
  • Polyinosinate:polycytidylate
  • Polyinosinic acid:polycytidylic acid
  • Polyinosinic acid:polycytidylic acid complex
  • Polyinosinic-polycytidylic acid
  • Polyinosinic-polycytidylic acid complex
  • Polyribocytidylic acid-polyriboinosinic acid complex
  • Polyriboinosinic acid-polyribocytidylic acid complex
  • Polyriboinosinic-polyribocytidylic acid
  • Polyriboinosinic-polyribocytidylic acid complex
  • Polyriboinosinic: polyribocytidylic acid
  • UNII-3R630IWW5I
  • UNII-O84C90HH2L

Systematic Names

  • 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1) (9CI)
  • 5'-Inosinic acid, polymers, complex with 5'-cytidylic acid polymers (1:1) (8CI)
  • Polyinosinic:polycytidylic acid copolymer

Registry Numbers

CAS Registry Number

  • 24939-03-5

FDA UNIIs

  • 3R630IWW5I
  • O84C90HH2L

System Generated Number

  • 0024939035

Molecular Formulas

Molecular Formula

  • (C10-H13-N4-O8-P)x-.(C9-H14-N3-O8-P)x-

Molecular Formula Fragments

  • C10-H13-N4-O8-P
  • C9-H14-N3-O8-P
  • COMPONENT

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo intravenous 15mg/kg (15mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 intraperitoneal 35mg/kg (35mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 intravenous 9500ug/kg (9.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 23, Pg. 579, 1972.
mouse LD50 parenteral 20mg/kg (20mg/kg) BEHAVIORAL: EXCITEMENT Nature. Vol. 223, Pg. 715, 1969.
rabbit LD50 intravenous 220ug/kg (0.22mg/kg) BLOOD: HEMORRHAGE

VASCULAR: OTHER CHANGES
Voprosy Virusologii. Problems of Virology. Vol. 23(2), Pg. 201, 1978.
rat LD50 intraperitoneal 365mg/kg (365mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.
rat LD50 intravenous 185mg/kg (185mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 18, Pg. 220, 1971.