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Substance Name: Butylated hydroxyanisole [BAN:NF]
RN: 25013-16-5
UNII: REK4960K2U

Note

  • Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.

Molecular Formula

  • C11-H16-O2

Molecular Weight

  • 181.2533
 

Classification Codes

Classification Codes

  • Antioxidants
  • Carcinogens
  • Mutation Data
  • Noxae
  • Pharmaceutic Aid (Antioxidant)
  • Protective Agents
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably Anticipated to be a Carcinogen

Names and Synonyms

Name of Substance

  • (1,1-Dimethylethyl)-4-methoxyphenol
  • BHA
  • Butylated hydroxyanisole
  • Butylated hydroxyanisole [BAN:NF]
  • Phenol, (1,1-dimethylethyl)-4-methoxy-

MeSH Heading

  • Butylated hydroxyanisole

Synonyms

  • (1,1-Dimethylethyl)-4-methoxyphenol
  • 2(3)-tert-Butyl-4-hydroxyanisole
  • 2-terc.Butyl-4-methoxyfenol
  • 2-terc.Butyl-4-methoxyfenol [Czech]
  • 3-tert-Butyl-4-hydroxyanisole
  • Anisole, butylated hydroxy-
  • Antioxyne B
  • Antrancine 12
  • BHA
  • BOA (antioxidant)
  • Butyl hydroxyanisole
  • Butylated hydroxyanisole
  • Butylhydroxyanisole
  • Butylohydroksyanizol
  • Butylohydroksyanizol [Polish]
  • CCRIS 102
  • EC 246-563-8
  • EEC No. E320
  • EINECS 246-563-8
  • Embanox
  • FEMA No. 2183
  • HSDB 3913
  • Nepantiox 1-F
  • Nipantiox 1-F
  • Phenol, (1,1-dimethylethyl)-4-methoxy-
  • Phenol, tert-butyl-4-methoxy-
  • Protex
  • Sustane 1-F
  • t-Butyl hydroxyanisole
  • Tenox BHA
  • tert-Butyl-4-hydroxyanisole
  • tert-Butyl-4-methoxyphenol
  • UNII-REK4960K2U

Systematic Names

  • Butylated hydroxyanisole
  • Phenol, (1,1-dimethylethyl)-4-methoxy-
  • tert-Butyl-4-methoxyphenol

Superlist Names

  • BHA
  • Butylated hydroxyanisole
  • Phenol, tert-butyl-4-methoxy-

Registry Numbers

CAS Registry Number

  • 25013-16-5

FDA UNII

  • REK4960K2U

Other Registry Numbers

  • 1336-31-8
  • 37349-77-2
  • 56587-66-7
  • 57534-28-8
  • 8003-24-5
  • 8041-81-4
  • 9009-68-1

System Generated Number

  • 0025013165

Structure Descriptors

Smiles

[*]C(C)(C)C.COc1ccc(O)cc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 1100mg/kg (1100mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970.
rabbit LD50 oral 2100mg/kg (2100mg/kg)   Journal of the American Oil Chemists' Society. Vol. 54, Pg. 239, 1977.
rat LD50 intraperitoneal 881mg/kg (881mg/kg) BLOOD: HEMORRHAGE Toxicology Letters. Vol. 27, Pg. 15, 1985.
rat LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 51 deg C   EXP
Boiling Point 268 deg C   EXP
log P (octanol-water) 3.500 (none)   EST
Water Solubility 213 mg/L 25 EST
Vapor Pressure 2.48E-03 mm Hg 25 EST
Henry's Law Constant 1.17E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.61E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.