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Substance Name: Gloxazone [USAN:INN:BAN]
RN: 2507-91-7
UNII: OP8B49OL1J
InChIKey: ARIFZLJIERKKEL-UHFFFAOYSA-N

Classification Codes

  • Anaplasmodastat (Veterinary)
  • Mutation Data

Molecular Formula

  • C8-H16-N6-O-S2

Molecular Weight

  • 276.3874
 
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Names and Synonyms

Name of Substance

  • Gloxazone
  • Gloxazone [USAN:INN:BAN]
  • Kethoxal bis(thiosemicarbazone)

Synonyms

  • (1-Ethoxyethyl)glyoxal bis(thiosemicarbazone)
  • 1,1'-((1-Ethoxyethyl)ethanediylidene)bis(3-thiosemicarbazide)
  • 2-Keto-3-ethoxy-butyraldehyde-bis(thiosemicarbazone)
  • 3-Ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone)
  • AI3-51304
  • alpha-Ethoxyethylglyoxal dithiosemicarbazone
  • B. W. 356-C-61
  • B.W. 356-C-61
  • BRN 1915287
  • BW 356-C-61
  • BW 356C61
  • Contrapar
  • EINECS 219-715-6
  • Gloxazon
  • Gloxazona
  • Gloxazona [INN-Spanish]
  • Gloxazone
  • Gloxazonum
  • Gloxazonum [INN-Latin]
  • Hydrazinecarbothioamide, 2,2'-(1-(1-ethoxyethyl)-1,2-ethanediylidene)bis
  • Hydrazinecarbothioamide, 2,2'-(1-(1-ethoxyethyl)-1,2-ethanediylidene)bis-
  • KC 1331
  • Kethoxal bis(thiosemicarbazone)
  • Kethoxal-bis-thiosemicarbazide
  • KTS (pharmaceutical)
  • NSC 82116
  • NSC-82116
  • Semicarbazide, 1,1'-((1-ethoxyethyl)ethanediylidene)bis(3-thio-
  • U 7726
  • U-7726
  • U7726
  • UNII-OP8B49OL1J
  • WR 9838

Systematic Names

  • Butyraldehyde, 3-ethoxy-2-oxo-, bis(thiosemicarbazone)
  • Gloxazone
  • Hydrazinecarbothioamide, 2,2'-(1-(1-ethoxyethyl)-1,2-ethanediylidene)bis-

Registry Numbers

CAS Registry Number

  • 2507-91-7

FDA UNII

  • OP8B49OL1J

System Generated Number

  • 0002507917

Structure Descriptors

InChI

1S/C8H16N6OS2/c1-3-15-5(2)6(12-14-8(10)17)4-11-13-7(9)16/h4-5H,3H2,1-2H3,(H3,9,13,16)(H3,10,14,17)

InChIKey

ARIFZLJIERKKEL-UHFFFAOYSA-N

Smiles

CCOC(C)C(=NNC(=S)N)C=NNC(=S)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intraperitoneal 100mg/kg (100mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Cancer Research. Vol. 25, Pg. 1417, 1965.
mouse LD50 subcutaneous > 1600mg/kg (1600mg/kg) BEHAVIORAL: ATAXIA Cancer Research. Vol. 25, Pg. 1417, 1965.
mouse LDLo intraperitoneal 1gm/kg (1000mg/kg)   Cancer Chemotherapy Reports. Vol. 30, Pg. 9, 1963.
rat LD50 intraperitoneal 440mg/kg (440mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: ATAXIA
Cancer Research. Vol. 25, Pg. 1417, 1965.
rat LD50 intravenous 182mg/kg (182mg/kg)   Chemotherapy Vol. 13, Pg. 339, 1968.
rat LD50 oral > 3200mg/kg (3200mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: ATAXIA
Cancer Research. Vol. 25, Pg. 1417, 1965.
rat LD50 subcutaneous 195mg/kg (195mg/kg) BEHAVIORAL: ATAXIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
Cancer Research. Vol. 25, Pg. 1417, 1965.