Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Clobetasol propionate [USAN:USP:JAN]
RN: 25122-46-7
UNII: 779619577M
InChIKey: CBGUOGMQLZIXBE-XGQKBEPLSA-N

Note

  • A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

Molecular Formula

  • C25-H32-Cl-F-O5

Molecular Weight

  • 466.9738
 

Classification Codes

  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Glucocorticoids
  • Hormone
  • Reproductive Effect
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Clobetasol propionate
  • Clobetasol propionate [USAN:USP:JAN]

Synonyms

  • 21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione (11beta,16beta)-
  • 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Butavate
  • CCI 4725
  • CGP 9555
  • Clobesol
  • Clobetasol 17-propionate
  • Clobetasol propionate
  • Clobetasol propionate (emollient)
  • Clobetasol propionate gel
  • Clobetasolpropionate
  • Clobex
  • Cormax
  • Dermoval
  • Dermovate
  • Dermoxinale
  • EINECS 246-634-3
  • Embeline
  • Embeline E
  • GR 2/925
  • Impoyz
  • Luxiq
  • Olux
  • Olux E
  • Olux-E
  • Temovate
  • Temovate E
  • UNII-779619577M
  • Yugofin

Systematic Names

  • 21-Chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • 21-Chloro-9-fluoro-11beta-hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-methyl-, 17-propionate
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)-

Superlist Name

  • Clobetasol propionate

Registry Numbers

CAS Registry Number

  • 25122-46-7

FDA UNII

  • 779619577M

System Generated Number

  • 0025122467

Structure Descriptors

InChI

1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

InChIKey

CBGUOGMQLZIXBE-XGQKBEPLSA-N

Smiles

CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 118mg/kg (118mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 subcutaneous 81700ug/kg (81.7mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 intraperitoneal 351mg/kg (351mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 oral > 3gm/kg (3000mg/kg)   Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 subcutaneous 366mg/kg (366mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 1066, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 195.5-197 deg C   EXP
log P (octanol-water) 3.5 (none)   EXP
Water Solubility 3.860 mg/L 25 EST
Vapor Pressure 2.72E-13 mm Hg 25 EST
Henry's Law Constant 2.32E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.75E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.