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Substance Name: Clobetasone butyrate [USAN:JAN]
RN: 25122-57-0
UNII: 8U0H6XI6EO
InChIKey: FBRAWBYQGRLCEK-AVVSTMBFSA-N
Molecular Formula
- C26-H32-Cl-F-O5
Molecular Weight
- 478.9848
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Adrenal Cortex Hormones
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Drug / Therapeutic Agent
- Glucocorticoids
- Hormone
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Clobetasone butyrate
- Clobetasone butyrate [USAN:JAN]
Synonyms
- 21-Chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione butyrate
- 21-Chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione butyrate
- CCI 5537
- Clobetasone 17-butyrate
- Clobetasone butyrate
- Cloptison
- EINECS 246-635-9
- Emovate
- Eumovate
- GR 2/1214
- Molivate
- Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16-beta)-
- SN 203
- UNII-8U0H6XI6EO
Systematic Names
- 21-Chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
- Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16beta)-
- Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-, butyrate
Registry Numbers
CAS Registry Number
- 25122-57-0
FDA UNII
- 8U0H6XI6EO
System Generated Number
- 0025122570
Structure Descriptors
InChI
InChI=1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1InChIKey
FBRAWBYQGRLCEK-AVVSTMBFSA-NSmiles
CCCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983. | |
mouse | LD50 | oral | > 6gm/kg (6000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
mouse | LD50 | subcutaneous | > 3600mg/kg (3600mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER BLOOD: CHANGES IN SPLEEN | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
rat | LD50 | intraperitoneal | 1510mg/kg (1510mg/kg) | BLOOD: OTHER CHANGES ENDOCRINE: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Journal of Toxicological Sciences. Vol. 5, Pg. 45, 1980. |
rat | LD50 | oral | > 6gm/kg (6000mg/kg) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
rat | LD50 | subcutaneous | > 2600mg/kg (2600mg/kg) | BLOOD: CHANGES IN SPLEEN BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Yakkyoku. Pharmacy. Vol. 35, Pg. 1473, 1984. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 90-100 | deg C | EXP | |
log P (octanol-water) | 3.76 | (none) | EXP | |
Water Solubility | 0.600 | mg/L | 25 | EST |
Vapor Pressure | 2.98E-11 | mm Hg | 25 | EST |
Henry's Law Constant | 3.21E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.03E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.