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Substance Name: Macrogol [INN]
RN: 25322-68-3

Notes

  • A tasteless laxative composed of PEG3350; Miralax is tradename.
  • Polymers of ETHYLENE OXIDE and water and their ethers. They vary in consistency from liquid to solid, depending on the molecular weight, indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are lauromagrogols, nonoxynols, octoxynols and poloxamers.

Molecular Formula

  • (C2-H4-O)mult-H2-O

Molecular Weight

  • 44.0526
 

Classification Codes

  • Drug / Therapeutic Agent
  • Excipients
  • Mutation Data
  • Pharmaceutic Aid (Ointment Base)
  • Pharmaceutic Aid (Solvent)
  • Pharmaceutic Aid (Suppository Base)
  • Pharmaceutic Aid (Suspending and/or Viscosity Agent)
  • Pharmaceutic Aid (Tablet and/or Capsule Lubricant)
  • Pharmaceutic Aid (Tablet Binder)
  • Pharmaceutic Aid (Tablet Excipient)
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles
  • Skin / Eye Irritant
  • Solvents
  • Surface-Active Agents
  • TSCA Flag XU (Exempt from Reporting under Chemical Data Reporting Rule)
  • Tumor Data

Names and Synonyms

Results Name

  • Macrogol [INN]

Name of Substance

  • Ethanol, 2,2'-(oxybis(2,1-ethanediyloxy)bis-
  • Macrogol [INN]
  • Polyethylene glycol
  • Polyethylene glycol 1000
  • Polyethylene glycol 1450
  • Polyethylene glycol 1500
  • Polyethylene glycol 1540
  • Polyethylene glycol 200
  • Polyethylene glycol 300
  • Polyethylene glycol 3350
  • Polyethylene glycol 3500
  • Polyethylene glycol 400
  • Polyethylene glycol 4000
  • Polyethylene glycol 4500
  • Polyethylene glycol 7000
  • Polyethylene glycol 800
  • Polyethylene glycol 8000
  • Polyethylene glycol 900
  • Polyethylene glycol [NF]
  • Polyox wsr-N 60

MeSH Heading

  • Polyethylene Glycols

Synonyms

  • 1,2-Ethanediol homopolymer
  • Alcox E 30
  • Alkox E 100
  • Alkox E 130
  • Alkox E 160
  • Alkox E 240
  • Alkox E 45
  • Alkox E 60
  • Alkox E 75
  • Alkox R 1000
  • Alkox R 15
  • Alkox R 150
  • Alkox R 400
  • Alkox SR
  • alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
  • alpha-Hydro-omega-hydroxypoly(oxyethylene)
  • Antarox E 4000
  • Aquacide III
  • Aquaffin
  • Atpeg 300
  • Atpeg 4000
  • Badimol
  • BDH 301
  • Bradsyn PEG
  • Breox 2000
  • Breox 20M
  • Breox 4000
  • Breox 550
  • Breox PEG 300
  • CAFO 154
  • Carbowax
  • Carbowax 100
  • Carbowax 1000
  • Carbowax 1350
  • Carbowax 14000
  • Carbowax 1500
  • Carbowax 1540
  • Carbowax 20
  • Carbowax 200
  • Carbowax 20000
  • Carbowax 25000
  • Carbowax 300
  • Carbowax 3350
  • Carbowax 400
  • Carbowax 4000
  • Carbowax 4500
  • Carbowax 4600
  • Carbowax 600
  • Carbowax 8000
  • Carbowax Sentry
  • CCRIS 979
  • Clearlax
  • DD 3002
  • Deactivator H
  • EC 500-038-2
  • EINECS 266-688-1
  • Emkapol 4200
  • Ethoxylated 1,2-ethanediol
  • Ethylene glycol homopolymer
  • Ethylene glycol polymer
  • Forlax
  • Gafanol E 200
  • Gavilax
  • Glycols, polyethylene
  • HM 500
  • HSDB 5159
  • Lutrol
  • Lutrol E
  • Macrogol
  • Macrogol 3350
  • Merpol OJ
  • Miralax
  • Modopeg
  • Nosilen
  • NSC 152324
  • Nycoline
  • Oxide Wax AN
  • Oxyethylene polymer
  • PEG
  • PEG 1000
  • PEG 1500
  • PEG 1540
  • PEG 200
  • PEG 300
  • PEG 3350
  • PEG 3500
  • PEG 400
  • PEG 4000
  • PEG 4500
  • PEG 6000DS
  • PEG 800
  • PEG 8o00
  • PEG 900
  • PEG-1000
  • PEG-1500
  • PEG-1540
  • PEG-200
  • PEG-300
  • PEG-3350
  • PEG-3500
  • PEG-4000
  • PEG-4500
  • PEG-800
  • PEG-8000
  • PEG-900
  • Plenvu
  • Pluracol E
  • Pluracol E 400, E 600, E 1450
  • Pluriol E 200
  • Poly(oxy-1,2-ethanediyl, alpha-hydro-omega-hydroxy-
  • Poly-G
  • Poly-G600
  • Polyethylene glycol
  • Polyethylene glycol 1000
  • Polyethylene glycol 1450
  • Polyethylene glycol 1500
  • Polyethylene glycol 1540
  • Polyethylene glycol 200
  • Polyethylene glycol 300
  • Polyethylene glycol 3350
  • Polyethylene glycol 3500
  • Polyethylene glycol 400
  • Polyethylene glycol 4000
  • Polyethylene glycol 4500
  • Polyethylene glycol 6000
  • Polyethylene glycol 7000
  • Polyethylene glycol 800
  • Polyethylene glycol 8000
  • Polyethylene glycol 900
  • Polyethylene oxide
  • Polyglycol E 300, E 400, E 1450, E 8000
  • Polyoxyethylene ether
  • Sentry polyox WSR
  • UNII-11628IH70O
  • UNII-1212Z7S33A
  • UNII-16P9295IIL
  • UNII-2126FD486L
  • UNII-30IQX730WE
  • UNII-3H4G04L531
  • UNII-3IG9032SAH
  • UNII-3WJQ0SDW1A
  • UNII-439X29GCJZ
  • UNII-4QIB4U4CQR
  • UNII-4R4HFI6D95
  • UNII-5246R0812J
  • UNII-5655G9Y8AQ
  • UNII-5IRA46LB71
  • UNII-5K3991GVWI
  • UNII-5WKN5KL2O8
  • UNII-74D3A2BP47
  • UNII-761NX2Q08Y
  • UNII-762678AC5R
  • UNII-77HY82S0LG
  • UNII-7Z3ER739EB
  • UNII-8EIY1IHX76
  • UNII-9XH9HVO466
  • UNII-FVS1AZD90Y
  • UNII-G2M7P15E5P
  • UNII-G3MS6M810Y
  • UNII-H57W405143
  • UNII-HAF0412YIT
  • UNII-HZ58M6D839
  • UNII-NL4J9F21N9
  • UNII-OJ4Z5Z32L4
  • UNII-Q0JET65GEL
  • UNII-Q662QK8M3B
  • UNII-R0XY39567G
  • UNII-RU64142H6P
  • UNII-RVV61677RZ
  • UNII-SA1B764746
  • UNII-TVH7653921
  • UNII-U076Q6Q621
  • UNII-U95VVU3IDQ
  • UNII-UEP843BRCQ
  • UNII-UH6KR4953D
  • UNII-V146K8QJ07
  • UNII-V46Y6OJ5QB
  • UNII-VM53EE110J
  • UNII-X83H03O8BZ
  • UNII-Y4QO2MSY3X

Systematic Names

  • Glycols, polyethylene (8CI)
  • Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-
  • Poly(oxy-1,2-ethanediyl),alpha-hydro-omega-hydroxy- ethane-1,2-diol, ethoxylated
  • Polyethylene glycol
  • WSR-301

Superlist Names

  • Glycols, polyethylene
  • PEG
  • Polyethylene glycol

Mixture Name

  • Colyte

Registry Numbers

CAS Registry Number

  • 25322-68-3

FDA UNIIs

  • 11628IH70O
  • 1212Z7S33A
  • 16P9295IIL
  • 2126FD486L
  • 30IQX730WE
  • 3H4G04L531
  • 3IG9032SAH
  • 3WJQ0SDW1A
  • 439X29GCJZ
  • 4QIB4U4CQR
  • 4R4HFI6D95
  • 5246R0812J
  • 5655G9Y8AQ
  • 5IRA46LB71
  • 5K3991GVWI
  • 5WKN5KL2O8
  • 74D3A2BP47
  • 761NX2Q08Y
  • 762678AC5R
  • 77HY82S0LG
  • 7Z3ER739EB
  • 8EIY1IHX76
  • 9XH9HVO466
  • FVS1AZD90Y
  • G2M7P15E5P
  • G3MS6M810Y
  • H57W405143
  • HAF0412YIT
  • HZ58M6D839
  • NL4J9F21N9
  • OJ4Z5Z32L4
  • Q0JET65GEL
  • Q662QK8M3B
  • R0XY39567G
  • RU64142H6P
  • RVV61677RZ
  • SA1B764746
  • TVH7653921
  • U076Q6Q621
  • U95VVU3IDQ
  • UEP843BRCQ
  • UH6KR4953D
  • V146K8QJ07
  • V46Y6OJ5QB
  • VM53EE110J
  • X83H03O8BZ
  • Y4QO2MSY3X

Other Registry Numbers

  • 1011711-38-8
  • 101677-86-5
  • 1033001-32-9
  • 1035554-64-3
  • 106186-24-7
  • 107502-63-6
  • 107529-96-4
  • 109550-27-8
  • 112384-37-9
  • 112895-21-3
  • 113041-64-8
  • 114323-93-2
  • 1152430-37-9
  • 116549-90-7
  • 1186292-40-9
  • 1186292-41-0
  • 119219-06-6
  • 1204298-97-4
  • 1221382-78-0
  • 1221382-83-7
  • 1221889-65-1
  • 1246265-64-4
  • 125223-68-9
  • 1256377-90-8
  • 1267533-36-7
  • 12676-74-3
  • 12770-93-3
  • 1287768-38-0
  • 1293291-01-6
  • 1319730-68-1
  • 1330618-78-4
  • 133573-31-6
  • 1338951-32-8
  • 134919-43-0
  • 1373256-89-3
  • 1377964-82-3
  • 1422717-42-7
  • 1429745-88-9
  • 1434253-80-1
  • 1435263-27-6
  • 1446681-77-1
  • 1474108-09-2
  • 150872-82-5
  • 154394-38-4
  • 156948-19-5
  • 1613520-06-1
  • 1620693-21-1
  • 1628723-15-8
  • 1636129-20-8
  • 169046-53-1
  • 1696472-65-7
  • 1710469-72-9
  • 174460-08-3
  • 174460-09-4
  • 1800416-42-5
  • 1809027-71-1
  • 1852508-98-5
  • 1873338-22-7
  • 188364-77-4
  • 188924-03-0
  • 189154-62-9
  • 191743-71-2
  • 1927875-70-4
  • 196696-84-1
  • 201163-43-1
  • 2015216-86-9
  • 206357-86-0
  • 2088235-52-1
  • 2092889-80-8
  • 2122851-44-7
  • 2170314-63-1
  • 221638-71-7
  • 225502-44-3
  • 25104-58-9
  • 25609-81-8
  • 270910-26-4
  • 307928-07-0
  • 34802-42-1
  • 356055-70-4
  • 37361-15-2
  • 391229-98-4
  • 402483-26-5
  • 411207-22-2
  • 497171-83-2
  • 50809-04-6
  • 50809-59-1
  • 51312-32-4
  • 54510-95-1
  • 54847-64-2
  • 59763-40-5
  • 60894-12-4
  • 615575-04-7
  • 61840-14-0
  • 64441-68-5
  • 64640-28-4
  • 67411-64-7
  • 6790-09-6
  • 70926-57-7
  • 75285-02-8
  • 75285-03-9
  • 77986-38-0
  • 79964-26-4
  • 80341-53-3
  • 8038-37-7
  • 85399-22-0
  • 857367-46-5
  • 859315-72-3
  • 85945-29-5
  • 863328-36-3
  • 876655-84-4
  • 88077-80-9
  • 886469-28-9
  • 88747-22-2
  • 90597-70-9
  • 9081-95-2
  • 9085-02-3
  • 9085-03-4
  • 952682-62-1
  • 956217-69-9
  • 959127-49-2
  • 99264-61-6
  • 99333-89-8

System Generated Number

  • 0025322683

Molecular Formulas

Molecular Formula

  • (C2-H4-O)mult-H2-O

Molecular Formula Fragments

  • C2-H4-O
  • COMPONENT
  • H2-O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3gm/kg (3000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
guinea pig LD50 oral 15700mg/kg (15700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 17gm/kg (17000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 19600mg/kg (19600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 22500mg/kg (22500mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
guinea pig LD50 oral 28gm/kg (28000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50900mg/kg (50900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 intraperitoneal 473mg/kg (473mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 21, Pg. 387, 1986.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intraperitoneal 7500mg/kg (7500mg/kg)   National Technical Information Service. Vol. AD628-313,
mouse LD50 intraperitoneal 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intravenous 7900ug/kg (7.9mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 intravenous 8550mg/kg (8550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 oral 28915mg/kg (28915mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
mouse LD50 oral 31gm/kg (31000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 34gm/kg (34000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 36gm/kg (36000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 subcutaneous 18gm/kg (18000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD skin > 1gm/kg (1000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rabbit LD50 intravenous 8gm/kg (8000mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 4, Pg. 71, 1978.
rabbit LD50 oral 14gm/kg (14000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 17300mg/kg (17300mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 17300mg/kg (17300mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 19gm/kg (19000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 26800mg/kg (26800mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 76gm/kg (76000mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 76gm/kg (76000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 skin > 20mL/kg (20mL/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2202,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-96,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-939,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD oral > 4gm/kg (4000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rat LD50 intraperitoneal 6790mg/kg (6790mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9gm/kg (9000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9700mg/kg (9700mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 9708mg/kg (9708mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
rat LD50 intraperitoneal 12600mg/kg (12600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 14100mg/kg (14100mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 15390mg/kg (15390mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 15570mg/kg (15570mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 17gm/kg (17000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 intraperitoneal 17700mg/kg (17700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intravenous 7130mg/kg (7130mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 7312mg/kg (7312mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 13gm/kg (13000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 600mg/kg (600mg/kg)   Dow Chemical Company Reports. Vol. MSD-94,
rat LD50 oral 1054mg/kg (1054mg/kg)   Dow Chemical Company Reports. Vol. MSD-95,
rat LD50 oral > 4gm/kg (4000mg/kg)   Dow Chemical Company Reports. Vol. MSD-938,
rat LD50 oral 22gm/kg (22000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 27500mg/kg (27500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 28gm/kg (28000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rat LD50 oral 30gm/kg (30000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rat LD50 oral 30200mg/kg (30200mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 oral 31600mg/kg (31600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 31640mg/kg (31640mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 32gm/kg (32000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rat LD50 oral 44200mg/kg (44200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 45gm/kg (45000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51200mg/kg (51200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51310mg/kg (51310mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 subcutaneous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 unreported 7800mg/kg (7800mg/kg)   United States Patent Document. Vol. #4767763,
rat LDLo intravenous 3mg/kg (3mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 442, 1970.
rat LDLo intravenous 22gm/kg (22000mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1087, 1973.