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Substance Name: Kanamycin sulfate [USP:JAN]
RN: 25389-94-0
UNII: J80EX28SMQ
InChIKey: OOYGSFOGFJDDHP-KMCOLRRFSA-N

Note

  • Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.

Molecular Formula

  • C18-H36-N4-O11.H2-O4-S

Molecular Weight

  • 582.5772
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Human Data
  • Natural Product
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Kanamycin sulfate
  • Kanamycin sulfate [USP:JAN]

Synonyms

  • Cantrex
  • Cristalomicina
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1-4))-2-deoxy-, sulfate (1:1) (salt)
  • EINECS 246-933-9
  • Kanabristol
  • Kanacedin
  • Kanamycin
  • Kanamycin A sulfate
  • Kanamycin acid sulfate
  • Kanamycin monosulfate
  • Kanamycin monosulfate [JAN]
  • Kanamycin sulfate
  • Kanamycin sulfate (1:1) (salt)
  • Kanamytrex
  • Kanaqua
  • Kanasig
  • Kanatrol
  • Kanescin
  • Kanicin
  • Kannasyn
  • Kano
  • Kantrex
  • Kantrim
  • Klebcil
  • Ophtalmokalixan
  • Otokalixin
  • UNII-J80EX28SMQ

Systematic Names

  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)
  • Kanamycin sulphate
  • Kanamycin, sulfate (1:1) (salt)

Mixture Name

  • Amforol (Veterinary)

Registry Numbers

CAS Registry Number

  • 25389-94-0

FDA UNII

  • J80EX28SMQ

Other Registry Numbers

  • 11030-21-0
  • 11033-61-7
  • 133-92-6

System Generated Number

  • 0025389940

Molecular Formulas

Molecular Formula

  • C18-H36-N4-O11.H2-O4-S

Molecular Formula Fragments

  • C18-H36-N4-O11
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChIKey

OOYGSFOGFJDDHP-KMCOLRRFSA-N

Smiles

C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intramuscular 390mg/kg (390mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR Journal of Pediatrics. Vol. 60, Pg. 230, 1962.
mouse LD50 intramuscular 1190mg/kg (1190mg/kg)   Drugs in Japan Vol. 6, Pg. 173, 1982.
mouse LD50 intraperitoneal 1353mg/kg (1353mg/kg)   Antimicrobial Agents and Chemotherapy Vol. -, Pg. 138, 1963.
mouse LD50 intravenous 240mg/kg (240mg/kg)   Drugs in Japan Vol. 6, Pg. 173, 1982.
mouse LD50 oral 17500mg/kg (17500mg/kg)   Drugs in Japan Vol. 6, Pg. 173, 1982.
mouse LD50 subcutaneous 1100mg/kg (1100mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Antibiotiki. Vol. 29, Pg. 851, 1984.
rabbit LD50 intramuscular > 3gm/kg (3000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rabbit LD50 intravenous 550mg/kg (550mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rabbit LD50 oral > 3gm/kg (3000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rabbit LD50 subcutaneous > 3gm/kg (3000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat LD50 intramuscular > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat LD50 intraperitoneal 3200mg/kg (3200mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat LD50 intravenous 225mg/kg (225mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat LD50 oral > 4gm/kg (4000mg/kg)   Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat LD50 subcutaneous 1700mg/kg (1700mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 597, 1962.