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Substance Name: Felbamate [USAN:INN]
RN: 25451-15-4
UNII: X72RBB02N8
InChIKey: WKGXYQFOCVYPAC-UHFFFAOYSA-N
Note
- A PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA RECEPTORS. It is used as an anticonvulsant, primarily for the treatment of SEIZURES in severe refractory EPILEPSY.
Molecular Formula
- C11-H14-N2-O4
Molecular Weight
- 238.2416
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Epileptic
- Anticonvulsants
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Excitatory Amino Acid Antagonists
- Human Data
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- 2-Phenyl-1,3-propanediol dicarbamate
- Felbamate
- Felbamate [USAN:INN]
MeSH Heading
- Felbamate
Synonyms
- 2-Phenyl-1,3-propanediol dicarbamate
- 4-06-00-05993 (Beilstein Handbook Reference)
- BRN 3345236
- Carbamic acid, 2-phenyltrimethylene ester
- EINECS 247-001-4
- Felbamate
- Felbamato
- Felbamato [Spanish]
- Felbamatum
- Felbamatum [Latin]
- Felbatol
- HSDB 7525
- NSC 759866
- UNII-X72RBB02N8
- W 554
- W-554
Systematic Names
- 1,3-Propanediol, 2-phenyl-, dicarbamate
- 2-Phenylpropane-1,3-diyl dicarbamate
Registry Numbers
CAS Registry Number
- 25451-15-4
FDA UNII
- X72RBB02N8
System Generated Number
- 0025451154
Structure Descriptors
InChI
InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15)InChIKey
WKGXYQFOCVYPAC-UHFFFAOYSA-NSmiles
NC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 659mg/kg (659mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toxicological Sciences. Vol. 45, Pg. 225, 1998. |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs of the Future. Vol. 11, Pg. 931, 1986. | |
| rat | LD50 | intraperitoneal | 1625mg/kg (1625mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Toxicological Sciences. Vol. 45, Pg. 225, 1998. |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Drugs of the Future. Vol. 11, Pg. 931, 1986. | |
| women | TDLo | oral | 24mg/kg/2D-I (24mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Annals of Pharmacotherpy. Vol. 29, Pg. 430, 1995. |
| women | TDLo | oral | 140mg/kg (140mg/kg) | BEHAVIORAL: SLEEP | Pediatric Emergency Care. Vol. 11, Pg. 369, 1995. |
| women | TDLo | oral | 1296mg/kg/18D (1296mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Pharmacotherapy Vol. 15, Pg. 260, 1995. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 151.5 | deg C | EXP | |
| log P (octanol-water) | 0.760 | (none) | EST | |
| Atmospheric OH Rate Constant | 2.40E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.