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Substance Name: Ribostamycin [INN:BAN]
RN: 25546-65-0
UNII: 2Q5JOU7T53
InChIKey: NSKGQURZWSPSBC-VVPCINPTSA-N

Note

  • A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.

Molecular Formula

  • C17-H34-N4-O10

Molecular Weight

  • 454.474
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Ribostamycin
  • Ribostamycin [INN:BAN]

MeSH Heading

  • Ribostamycin

Synonyms

  • Antibiotic SF 733
  • BRN 1357280
  • Bu 1709
  • Dekamycin IV
  • EINECS 247-091-5
  • Hetangmycin
  • NSC 138925
  • O-2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxystreptamine
  • Ribastamin
  • Ribostamicina
  • Ribostamicina [INN-Spanish]
  • Ribostamycin
  • Ribostamycine
  • Ribostamycine [INN-French]
  • Ribostamycinum
  • Ribostamycinum [INN-Latin]
  • SF 733
  • UNII-2Q5JOU7T53
  • Vistamycin
  • Xylostatin

Systematic Names

  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)- O-(beta-D-ribofuranosyl-(1-5))-2-deoxy-
  • D-Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxy- (8CI)(9CI)
  • O-2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)-O-(beta-D-ribofuranosyl-(1->5))-2-deoxystreptamine
  • Ribostamycin

Registry Numbers

CAS Registry Number

  • 25546-65-0

FDA UNII

  • 2Q5JOU7T53

System Generated Number

  • 0025546650

Structure Descriptors

InChI

1S/C17H34N4O10/c18-2-6-10(24)12(26)8(21)16(28-6)30-14-5(20)1-4(19)9(23)15(14)31-17-13(27)11(25)7(3-22)29-17/h4-17,22-27H,1-3,18-21H2/t4-,5+,6-,7-,8-,9+,10-,11-,12-,13-,14-,15-,16-,17+/m1/s1

InChIKey

NSKGQURZWSPSBC-VVPCINPTSA-N

Smiles

O([C@H]1[C@H](O[C@H]2O[C@@H]([C@@H](O)[C@@H]([C@H]2N)O)CN)[C@H](C[C@H]([C@@H]1O)N)N)[C@@H]1O[C@H](CO)[C@H]([C@H]1O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intracrebral 66800ug/kg (66.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970.
mouse LD50 intramuscular 1600mg/kg (1600mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 141, 1980.
mouse LD50 intraperitoneal 2830mg/kg (2830mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
mouse LD50 intravenous 300mg/kg (300mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
mouse LD50 oral 7gm/kg (7000mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 141, 1980.
mouse LD50 subcutaneous 3350mg/kg (3350mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
rat LD50 intramuscular 1850mg/kg (1850mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Chemotherapy Vol. 32, Pg. 949, 1984.
rat LD50 intraperitoneal 4400mg/kg (4400mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
rat LD50 intravenous 535mg/kg (535mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
rat LD50 oral > 10gm/kg (10000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.
rat LD50 subcutaneous > 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2464, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 193.5 deg C   EXP
pKa Dissociation Constant 7.7 (none)   EXP
log P (octanol-water) -8.050 (none)   EST
Atmospheric OH Rate Constant 3.06E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.