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Substance Name: Molsidomine [USAN:INN:BAN:JAN]
RN: 25717-80-0
UNII: D46583G77X
InChIKey: XLFWDASMENKTKL-UHFFFAOYSA-N

Note

  • A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.

Molecular Formula

  • C9-H14-N4-O4

Molecular Weight

  • 242.2336
 

Classification Codes

  • Anti-Anginal
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Nitric Oxide Donors
  • Vasodilator (Coronary)
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Molsidomine
  • Molsidomine [USAN:INN:BAN:JAN]

MeSH Heading

  • Molsidomine

Synonyms

  • BRN 3999414
  • CAS 276
  • Corvaton
  • Covarsal
  • EINECS 247-207-4
  • Molsidolat
  • Molsidomina
  • Molsidomina [INN-Spanish]
  • Molsidomine
  • Molsidominum
  • Molsidominum [INN-Latin]
  • Morial
  • Morsydomine
  • Motazomin
  • N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnone imine
  • N-Carboxy-3-morpholinosydnone imine ethyl ester
  • N-Carboxy-3-morpholinosydnonimine ethyl ester
  • N-Ethoxycarbonyl-3-morpholinosydnonimine
  • SIN-10
  • UNII-D46583G77X

Systematic Names

  • Molsidomine
  • Sydnone imine, N-(ethoxycarbonyl)-3-(4-morpholinyl)-
  • Sydnone imine, N-carboxy-3-morpholino-, ethyl ester

Registry Numbers

CAS Registry Number

  • 25717-80-0

FDA UNII

  • D46583G77X

System Generated Number

  • 0025717800

Structure Descriptors

InChI

1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3

InChIKey

XLFWDASMENKTKL-UHFFFAOYSA-N

Smiles

CCOC(=O)[N-]c1c[n+](no1)N2CCOCC2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 910mg/kg (910mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
mouse LD50 intraperitoneal 700mg/kg (700mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
mouse LD50 intravenous 800mg/kg (800mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
mouse LD50 oral 830mg/kg (830mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
mouse LD50 subcutaneous 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
rat LD50 intramuscular 1320mg/kg (1320mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
rat LD50 intraperitoneal 1250mg/kg (1250mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
rat LD50 intravenous 760mg/kg (760mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
rat LD50 oral 1050mg/kg (1050mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.
rat LD50 subcutaneous 1350mg/kg (1350mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 17, Pg. 26, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 140.5 deg C   EXP
log P (octanol-water) -7.440 (none)   EST
Atmospheric OH Rate Constant 1.44E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.