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Substance Name: Gemfibrozil [USAN:USP:INN:BAN]
RN: 25812-30-0
UNII: Q8X02027X3
InChIKey: HEMJJKBWTPKOJG-UHFFFAOYSA-N

Note

  • A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.

Molecular Formula

  • C15-H22-O3

Molecular Weight

  • 250.3358
 

Classification Codes

Classification Codes

  • Antihyperlipidemic
  • Antimetabolites
  • Cytochrome P-450 CYP2C8 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Gemfibrozil
  • Gemfibrozil [USAN:USP:INN:BAN]

MeSH Heading

  • Gemfibrozil

Synonyms

  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
  • 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
  • 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
  • 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
  • Apo-Gemfibrozil
  • Ausgem
  • Bolutol
  • BRN 1881200
  • Brozil
  • CCRIS 318
  • Cholespid
  • CI 719
  • CI-719
  • Clearol
  • Decrelip
  • EINECS 247-280-2
  • Elmogan
  • Fetinor
  • Fibratol
  • Fibrocit
  • Gem-S
  • Gemd
  • Gemfibril
  • Gemfibromax
  • Gemfibrozil
  • Gemfibrozilo
  • Gemfibrozilo [INN-Spanish]
  • Gemfibrozilum
  • Gemfibrozilum [INN-Latin]
  • Gemlipid
  • Gemnpid
  • Gevilon Uno
  • Gozid
  • Hidil
  • Hipolixan
  • HSDB 7735
  • Innogen
  • Ipolipid
  • Jezil
  • Lanaterom
  • Lifibron
  • Lipazil
  • Lipigem
  • Lipira
  • Lipizyl
  • Lipur
  • Litarek
  • Lopid
  • Low-Lip
  • Micolip
  • Normolip
  • Pilder
  • Polyxit
  • Progemzal
  • Reducel
  • Regulip
  • Renabrazin
  • Sinelip
  • Synbrozil
  • Taborcil
  • Tentroc
  • Trialmin
  • UNII-Q8X02027X3
  • WL-Gemfibrozil

Systematic Names

  • Gemfibrozil
  • Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
  • Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-

Superlist Name

  • Gemfibrozil

Registry Numbers

CAS Registry Number

  • 25812-30-0

FDA UNII

  • Q8X02027X3

System Generated Number

  • 0025812300

Structure Descriptors

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChIKey

HEMJJKBWTPKOJG-UHFFFAOYSA-N

Smiles

Cc1ccc(c(c1)OCCCC(C)(C)C(=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 2gm/kg (2000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25, Pg. 699, 1997.
man TDLo oral 18gm/kg/3Y-I (18000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Archives of Internal Medicine. Vol. 151, Pg. 1873, 1991.
mouse LD50 oral 2218mg/kg (2218mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toksikologicheskii Vestnik. Vol. (6), Pg. 38, 1995.
rat LD50 intraperitoneal 445mg/kg (445mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toksikologicheskii Vestnik. Vol. (6), Pg. 38, 1995.
rat LD50 oral 1414mg/kg (1414mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25, Pg. 645, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 62 deg C   EXP
log P (octanol-water) 4.770 (none)   EST
Atmospheric OH Rate Constant 8.24E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.