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Substance Name: Gemfibrozil [USAN:USP:INN:BAN]
RN: 25812-30-0
UNII: Q8X02027X3
InChIKey: HEMJJKBWTPKOJG-UHFFFAOYSA-N

Note

  • A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.

Molecular Formula

  • C15-H22-O3

Molecular Weight

  • 250.3358
 

Classification Codes

Classification Codes

  • Antihyperlipidemic
  • Antimetabolites
  • Cytochrome P-450 CYP2C8 Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Metabolic Side Effects of Drugs and Substances
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3

Names and Synonyms

Name of Substance

  • Gemfibrozil
  • Gemfibrozil [USAN:USP:INN:BAN]

MeSH Heading

  • Gemfibrozil

Synonyms

  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
  • 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
  • 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
  • 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
  • Apo-Gemfibrozil
  • Ausgem
  • Bolutol
  • BRN 1881200
  • Brozil
  • CCRIS 318
  • Cholespid
  • CI 719
  • CI-719
  • Clearol
  • Decrelip
  • EINECS 247-280-2
  • Elmogan
  • Fetinor
  • Fibratol
  • Fibrocit
  • Gem-S
  • Gemd
  • Gemfibril
  • Gemfibromax
  • Gemfibrozil
  • Gemfibrozilo
  • Gemfibrozilo [INN-Spanish]
  • Gemfibrozilum
  • Gemfibrozilum [INN-Latin]
  • Gemlipid
  • Gemnpid
  • Gevilon Uno
  • Gozid
  • Hidil
  • Hipolixan
  • HSDB 7735
  • Innogen
  • Ipolipid
  • Jezil
  • Lanaterom
  • Lifibron
  • Lipazil
  • Lipigem
  • Lipira
  • Lipizyl
  • Lipur
  • Litarek
  • Lopid
  • Low-Lip
  • Micolip
  • Normolip
  • Pilder
  • Polyxit
  • Progemzal
  • Reducel
  • Regulip
  • Renabrazin
  • Sinelip
  • Synbrozil
  • Taborcil
  • Tentroc
  • Trialmin
  • UNII-Q8X02027X3
  • WL-Gemfibrozil

Systematic Names

  • Gemfibrozil
  • Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
  • Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-

Superlist Name

  • Gemfibrozil

Registry Numbers

CAS Registry Number

  • 25812-30-0

FDA UNII

  • Q8X02027X3

System Generated Number

  • 0025812300

Structure Descriptors

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChIKey

HEMJJKBWTPKOJG-UHFFFAOYSA-N

Smiles

Cc1ccc(c(c1)OCCCC(C)(C)C(=O)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 2gm/kg (2000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25, Pg. 699, 1997.
man TDLo oral 18gm/kg/3Y-I (18000mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BEHAVIORAL: MUSCLE WEAKNESS
Archives of Internal Medicine. Vol. 151, Pg. 1873, 1991.
mouse LD50 oral 2218mg/kg (2218mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toksikologicheskii Vestnik. Vol. (6), Pg. 38, 1995.
rat LD50 intraperitoneal 445mg/kg (445mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Toksikologicheskii Vestnik. Vol. (6), Pg. 38, 1995.
rat LD50 oral 1414mg/kg (1414mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25, Pg. 645, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 62 deg C   EXP
log P (octanol-water) 4.770 (none)   EST
Atmospheric OH Rate Constant 8.24E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.