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Substance Name: Nonoxynols
RN: 26027-38-3

Note

  • Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.

Molecular Formula

  • (C2-H4-O)mult-C15-H24-O

Molecular Weight

  • 264.406
 

Classification Codes

  • Antispermatogenic Agents
  • Contraceptive Agents
  • Contraceptive Agents, Female
  • Mutation Data
  • Noxae
  • Pharmaceutic Aid (Surfactant)
  • Pharmaceutic Aid (Wetting and or Solubilizing Agent)
  • Pharmaceutic Aid (Wetting and/or Solubilizing Agent)
  • Reproductive Control Agents
  • Reproductive Effect
  • Spermaticide
  • Spermatocidal Agents
  • Surface-Active Agents
  • TSCA Flag S (Substance is Identified in a Proposed or Final SNUR (Significant New Use Rule) under TSCA)

Names and Synonyms

Results Name

  • Nonoxynols

Name of Substance

  • Nonoxinol [INN]
  • Nonoxynol
  • Nonoxynol 15 [USAN]
  • Nonoxynol 30 [USAN]
  • Nonoxynol 4 [USAN]
  • Nonoxynol 9 [USAN:USP]
  • Nonoxynol-14
  • Nonoxynol-18
  • Nonoxynol-50
  • Nonoxynol-7
  • Nonoxynols
  • PEG-14 Nonyl phenyl ether
  • PEG-18 Nonyl phenyl ether
  • PEG-50 Nonyl phenyl ether
  • PEG-7 Nonyl phenyl ether
  • Polyethylene glycol (14) nonyl phenyl ether
  • Polyethylene glycol (18) nonyl phenyl ether
  • Polyethylene glycol (50) nonyl phenyl ether
  • Polyethylene glycol (7) nonyl phenyl ether
  • Polyethylene glycol 100 nonyl phenyl ether
  • Polyoxyethylene (14) nonyl phenyl ether
  • Polyoxyethylene (18) nonyl phenyl ether
  • Polyoxyethylene (50) nonyl phenyl ether
  • Polyoxyethylene (7) nonyl phenyl ether

MeSH Heading

  • Nonoxynol

Synonyms

  • 4-Nonylphenol decaglycol ether
  • Advantage 24
  • Akyporox NP 150
  • alpha-(p-Nonylphenyl)-omega-hydroxydeca(oxyethylene)
  • alpha-(p-Nonylphenyl)-omega-hydroxynona(oxyethylene)
  • alpha-(p-Nonylphenyl)-omega-hydroxypentadeca(oxyethylene)
  • alpha-(p-Nonylphenyl)-omega-hydroxypoly(oxyethylene)
  • alpha-(p-Nonylphenyl)-omega-hydroxytetra(oxyethylene)
  • alpha-(p-Nonylphenyl)-omega-hydroxytriaconta(oxyethylene)
  • Amway All Purpose Spray Adjuvant
  • Amway APSA 80
  • APSA 80
  • Bion NE 9
  • CCRIS 8448
  • Conceptrol
  • Cremophor NP 10
  • Cremophor NP 14
  • Decaethylene glycol mono(p-nonylphenyl) ether
  • Decaethylene glycol p-nonylphenyl ether
  • Delfen
  • Egyptol
  • Emko
  • Emulan 30
  • Emulan 40
  • Encare oval
  • Ethoxylated p-nonyl phenol
  • Gynol II
  • HSDB 7217
  • Hyoxyd X 100
  • Hyoxyd X 200
  • Hyoxyd X 400
  • Iconol NP 100
  • Imbetin N 7A
  • Intercept
  • K-Y Plus
  • Koromex
  • Liponox NCY
  • Monopol NP 1013
  • Monopol NP 1060
  • N 100
  • Newcol 565
  • Nonoxinol
  • Nonoxinol 15
  • Nonoxinol 30
  • Nonoxinol 4
  • Nonoxinol 9
  • Nonoxynol
  • Nonoxynol 10
  • Nonoxynol 13
  • Nonoxynol 14
  • Nonoxynol 15
  • Nonoxynol 30
  • Nonoxynol 4
  • Nonoxynol 6
  • Nonoxynol 8.5
  • Nonoxynol 9
  • Nonoxynol-9
  • Nonylphenoxypoly(ethyleneoxy)ethanol
  • NOP 17
  • NOP 8
  • NP 8.5
  • NP-9
  • p-Nonylphenol decaethylene glycol ether
  • p-Nonylphenol polyethylene glycol ether
  • p-Nonylphenol-polyethylene glycol adduct
  • p-Nonylphenyl polyoxyethylene ether
  • Pannox 110
  • Pannox 111
  • Pannox 116
  • Phenol, p-nonyl-, monoether with polyethylene glycol
  • Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy
  • Polyethylene glycol mono(p-nonylphenyl) ether
  • Polyoxyethylated-p-nonyl phenol
  • Polyoxyethylene nonylphenyl ether
  • Semicid
  • Today Sponge
  • UNII-1F75BOT2DZ
  • UNII-3X709X44TE
  • UNII-4867M0AEJI
  • UNII-48Q180SH9T
  • UNII-5V4827GL2O
  • UNII-60ZT1XYO5N
  • UNII-6FW840C8W9
  • UNII-6NR43D77O6
  • UNII-8869L92EOT
  • UNII-A906T4D368
  • UNII-BK168521Q8
  • UNII-E9AU396Z19
  • UNII-ED8J5T817W
  • UNII-GV32KR898G
  • UNII-HR8408HWGL
  • UNII-JJX07DG188
  • UNII-K7O76887AP
  • UNII-KND68343W4
  • UNII-M693M091RR
  • UNII-OSD2GAP7HY

Systematic Names

  • Glycols, polyethylene, mono(p-nonylphenyl) ether
  • Poly(oxy-1,2-ethanediyl), alpha-(4-nonylphenyl)-omega-hydroxy-

Superlist Name

  • p-Nonylphenol, ethoxylated

Mixture Names

  • Delfen
  • Gentersal
  • Ortho-Creme

Registry Numbers

CAS Registry Number

  • 26027-38-3

FDA UNIIs

  • 1F75BOT2DZ
  • 3X709X44TE
  • 4867M0AEJI
  • 48Q180SH9T
  • 5V4827GL2O
  • 60ZT1XYO5N
  • 6FW840C8W9
  • 6NR43D77O6
  • 8869L92EOT
  • A906T4D368
  • BK168521Q8
  • E9AU396Z19
  • ED8J5T817W
  • GV32KR898G
  • HR8408HWGL
  • JJX07DG188
  • K7O76887AP
  • KND68343W4
  • M693M091RR
  • OSD2GAP7HY

Other Registry Numbers

  • 100777-03-5
  • 102735-76-2
  • 113595-38-3
  • 117989-54-5
  • 120038-12-2
  • 124401-72-5
  • 12612-63-4
  • 131160-29-7
  • 1338788-01-4
  • 135229-74-2
  • 190386-13-1
  • 195065-75-9
  • 204842-55-7
  • 226924-41-0
  • 27942-26-3
  • 28776-15-0
  • 29319-48-0
  • 34149-89-8
  • 37330-04-4
  • 374934-72-2
  • 39042-04-1
  • 52440-21-8
  • 52440-22-9
  • 55247-80-8
  • 56214-26-7
  • 58339-76-7
  • 68858-84-4
  • 69154-14-9
  • 70025-66-0
  • 78009-08-2
  • 86243-62-1
  • 86727-29-9
  • 9002-95-3
  • 96827-50-8
  • 96827-63-3
  • 99550-41-1

Related Registry Numbers

  • 31691-97-1 (4-sulfate, ammonium salt)
  • 9014-90-8 (1(4)-sulfate, hydrochloride salt)

System Generated Number

  • 0026027383

Molecular Formulas

Molecular Formula

  • (C2-H4-O)mult-C15-H24-O

Molecular Formula Fragments

  • C15-H24-O
  • C2-H4-O
  • COMPONENT

Structure Descriptors

Smiles

c1(ccc(OCCO)cc1)CCCCCCCCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 840uL/kg (0.84mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Contraception. Vol. 33, Pg. 1, 1986.
mouse LD50 oral 4290uL/kg (4.29mL/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 oral 620uL/kg (0.62mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin 1800uL/kg (1.8mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin 2mL/kg (2mL/kg)   Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin 2500uL/kg (2.5mL/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin 2830uL/kg (2.83mL/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin 3970uL/kg (3.97mL/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rabbit LD50 skin > 10gm/kg (10000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 intraperitoneal 210mg/kg (210mg/kg)   Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 1410uL/kg (1.41mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 3670uL/kg (3.67mL/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 3730uL/kg (3.73mL/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 5100uL/kg (5.1mL/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 1300mg/kg (1300mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 1980mg/kg (1980mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 2500mg/kg (2500mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 3550mg/kg (3550mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: TREMOR
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 oral 4300mg/kg (4300mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.
rat LD50 subcutaneous 1gm/kg (1000mg/kg)   Journal of the American College of Toxicology. Vol. 2(7), Pg. 35, 1983.