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Substance Name: Griselimycin
RN: 26034-16-2
InChIKey: BVCBJSHZCAWDPE-RENOUVQNSA-N

Note

  • An antitubercular agent; isolated from Streptomyces.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C57-H96-N10-O12

Molecular Weight

  • 1113.44
 
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Names and Synonyms

Synonyms

  • Griselimycin
  • GRISELIMYCINE
  • Grisellimycin
  • Grisellimycin B
  • Grizelimycin
  • NSC 246122
  • RP-11072-B

Systematic Name

  • Griselimycin

Registry Numbers

CAS Registry Number

  • 26034-16-2

System Generated Number

  • 0026034162

Structure Descriptors

InChI

1S/C57H96N10O12/c1-19-34(10)43-54(75)62(16)46(31(6)7)56(77)65-24-22-23-39(65)52(73)63(17)47(36(12)21-3)50(71)58-27-42(69)79-37(13)48(51(72)60-44(35(11)20-2)55(76)66-28-32(8)25-40(66)49(70)59-43)64(18)53(74)41-26-33(9)29-67(41)57(78)45(30(4)5)61(15)38(14)68/h30-37,39-41,43-48H,19-29H2,1-18H3,(H,58,71)(H,59,70)(H,60,72)/t32-,33-,34?,35?,36?,37-,39+,40-,41?,43+,44+,45+,46-,47-,48+/m1/s1

InChIKey

BVCBJSHZCAWDPE-RENOUVQNSA-N

Smiles

C1C[C@H]2C(N([C@H]([C@@H](C)CC)C(=O)NCC(O[C@@H]([C@@H](C(N[C@@H]([C@@H](C)CC)C(N3[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N([C@@H](C(N2C1)=O)C(C)C)C)C[C@H](C)C3)=O)=O)N(C)C([C@@H]1N(C[C@@H](C1)C)C(=O)[C@H](C(C)C)N(C)C(C)=O)=O)C)=O)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 1gm/kg (1000mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 164, 1980.
mouse LD50 subcutaneous 1250mg/kg (1250mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(2), Pg. 164, 1980.