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Substance Name: Diflucortolone [USAN:INN:BAN]
RN: 2607-06-9
UNII: K253365DXI
InChIKey: OGPWIDANBSLJPC-RFPWEZLHSA-N

Note

  • A topical glucocorticoid used in various DERMATOSES. It is absorbed through the skin, bound to plasma albumin, and may cause adrenal suppression. It is also administered as the valerate.

Molecular Formula

  • C22-H28-F2-O4

Molecular Weight

  • 394.4552
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Glucocorticoid
  • Glucocorticoids
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
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Names and Synonyms

Name of Substance

  • Diflucortolone
  • Diflucortolone [USAN:INN:BAN]

MeSH Heading

  • Diflucortolone

Synonyms

  • 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • Diflucortolona
  • Diflucortolona [INN-Spanish]
  • Diflucortolone
  • Diflucortolonum
  • Diflucortolonum [INN-Latin]
  • EINECS 220-022-6
  • UNII-K253365DXI

Systematic Names

  • Diflucortolone
  • Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 2607-06-9

FDA UNII

  • K253365DXI

System Generated Number

  • 0002607069

Structure Descriptors

InChI

1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1

InChIKey

OGPWIDANBSLJPC-RFPWEZLHSA-N

Smiles

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 242 deg C   EXP
log P (octanol-water) 1.960 (none)   EST
Atmospheric OH Rate Constant 6.14E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.