|
|
Substance Name: Amiloride [INN:BAN]
RN: 2609-46-3
UNII: 7DZO8EB0Z3
InChIKey: XSDQTOBWRPYKKA-UHFFFAOYSA-N
Note
- A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Molecular Formula
- C6-H8-Cl-N7-O
Molecular Weight
- 229.63
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Physical Properties
Classification Codes
- Acid Sensing Ion Channel Blockers
- Diuretics
- Diuretics, Potassium Sparing
- Epithelial Sodium Channel Blockers
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Channel Blockers
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Amiloride
- Amiloride [INN:BAN]
MeSH Heading
- Amiloride
Synonyms
- Amilorida
- Amilorida [INN-Spanish]
- Amiloride
- Amiloridum
- Amiloridum [INN-Latin]
- Amipramidin
- Amipramizid
- CCRIS 6545
- EINECS 220-024-7
- Guanamprazin
- N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
- N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
- UNII-7DZO8EB0Z3
Systematic Names
- Amiloride
- Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
Registry Numbers
CAS Registry Number
- 2609-46-3
FDA UNII
- 7DZO8EB0Z3
Related Registry Numbers
- 17440-83-4 (hydrochloride)
- 2016-88-8 (anhydrous hydrochloride)
System Generated Number
- 0002609463
Structure Descriptors
InChI
1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)InChIKey
XSDQTOBWRPYKKA-UHFFFAOYSA-NSmiles
c1(nc(c(nc1N)Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 241 | deg C | EXP | |
log P (octanol-water) | 0.090 | (none) | EST | |
Atmospheric OH Rate Constant | 2.13E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.