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Substance Name: Naproxen sodium [USAN:USP]
RN: 26159-34-2
UNII: 9TN87S3A3C
InChIKey: CDBRNDSHEYLDJV-FVGYRXGTSA-M

Note

  • An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Molecular Formulas

  • C14-H13-Na-O3
  • C14-H14-O3.Na

Molecular Weight

  • 252.2437
 

Classification Codes

  • Analgesic
  • Anti-Inflammatory
  • Antipyretic
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Naproxen sodium [USAN:USP]

Synonyms

  • (-)-Sodium (S)-6-methoxy-alpha-methyl-2-naphthaleneacetate
  • A-Nox
  • Aleve
  • Anapran
  • Anaprotab
  • Anaprox
  • Anaprox DS
  • Apo-Napro-Na
  • Aprol
  • Aprowell
  • Axer Alfa
  • BAY H6689
  • BAYH6689
  • Causalon Pro
  • Diocodal
  • Dysmenalgit
  • EINECS 247-486-2
  • Flanax
  • Flogen
  • Floginex
  • Flogogin
  • Floneks
  • Floxalin
  • Gibinap
  • Gibixen
  • Kapnax
  • Karoksen
  • L-(-)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
  • Laser
  • Leniartril
  • Miranax
  • Monarit
  • Naixan
  • Naprelan
  • Naprium
  • Naprodil
  • Naprodol
  • Naprosyn
  • Naprovite
  • Naproxen natrium
  • Naproxen sodium
  • Naprux
  • Naprux Gesic
  • Natrioxen
  • Nixal
  • Opraks
  • Pactens
  • Prexan
  • Primeral
  • Proxen
  • RS 3650
  • RS-3650
  • Sodimax
  • Sodium naproxen
  • Sunprox
  • Synflex
  • Tandax
  • Topcare all day pain relief
  • UNII-9TN87S3A3C
  • Veradol
  • Xenar

Systematic Names

  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-
  • 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, L-(-)-
  • Sodium (-)-2-(6-methoxy-2-naphthyl)propionate

Registry Numbers

CAS Registry Number

  • 26159-34-2

FDA UNII

  • 9TN87S3A3C

System Generated Number

  • 0026159342

Molecular Formulas

Molecular Formulas

  • C14-H13-Na-O3
  • C14-H14-O3.Na

Molecular Formula Fragments

  • C14-H14-O3
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

InChIKey

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Smiles

c12c(cc(cc2)OC)ccc(c1)[C@@H](C(=O)[O-])C.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 600mg/kg/30D- (600mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988.